Publication Name	World Journal of Gastroenterology
Manuscript ID	53151
Country	Italy

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Silymarin, boswellic acid and curcumin enriched dietetic formulation reduces the growth of inherited intestinal polyps in an animal model
Manuscript Source	Invited Manuscript
All Author List	Bruna Girardi, Maria Pricci, Floriana Giorgio, Mariano Piazzolla, Andrea Iannone, Giuseppe Losurdo, Mariabeatrice Principi, Michele Barone, Enzo Ierardi and Alfredo Di Leo
Funding Agency and Grant Number
Corresponding Author	Alfredo Di Leo, MD, PhD, Full Professor, Section of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, Piazza Giulio Cesare 11, Bari 70124, Italy. alfredo.dileo@uniba.it
Key Words	Intestinal cancer; Familial adenomatous polyposis; Chemopreventive diet; ApcMin/+ mice; Boswellia; Curcumin
Core Tip	A dietetic formulation containing silymarin, boswellic acid and curcumin has shown “in vitro” and “in vivo” anti-carcinogenetic properties in animal model of inflammation-related intestinal carcinoma. Herein, we assessed whether it may prevent inherited intestinal cancer in animal model (adenomatous polyposis coli multiple intestinal neoplasia - ApcMin/+). Our results showed that the dietetic formulation reduced polypoid lesion number and size on autoptic tissue, histological dysplasia and neoplasia areas. This effect is related to increased epithelial renewal and apoptosis and decreased proliferation. Our data are suggestive of a chemo-preventive synergic effect of the components of the dietetic formulation in inherited intestinal carcinoma.
Citation	Girardi B, Pricci M, Giorgio F, Piazzolla M, Iannone A, Losurdo G, Principi M, Barone M, Ierardi E, Di Leo A. Silymarin, boswellic acid and curcumin enriched dietetic formulation reduces the growth of inherited intestinal polyps in an animal model. World J Gastroenterol 2020; 26(14): 1601-1612

Received	2019-12-10 16:03
Peer-Review Started	2019-12-07 14:55
To Make the First Decision
Return for Revision	2019-12-30 12:10
Revised	2020-03-06 15:46
Second Decision	2020-03-26 11:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-03-26 21:11
Articles in Press	2020-03-26 21:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-04-13 09:40

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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