Publication Name	World Journal of Diabetes
Manuscript ID	53265
Country	France

Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Maternal low protein diet induces persistent expression changes in metabolic genes in male rats
Manuscript Source	Invited Manuscript
All Author List	Allan de Oliveira Lira, José Luiz de Brito Alves, Mariana Pinheiro Fernandes, Diogo Vasconcelos, David Filipe Santana, João Henrique da Costa-Silva, Béatrice Morio, Carol Góis Leandro and Luciano Pirola
Funding Agency and Grant Number	Funding Agency Grant Number the CAPES/COFECUB 797-14 the National Council for Research – Brazil 477915/2012-4
Corresponding Author	Luciano Pirola, PhD, Senior Researcher, Carmen (Cardiology, Metabolism and Nutrition) Laboratory, INSERM U1060, Lyon-1 University，South Lyon Medical Faculty Sector 2, CENS ELI-2D building, 165 Chemin du grand Revoyet, Pierre Benite 69310, France. luciano.pirola@univ-lyon1.fr
Key Words	Metabolic adaptation; Phenotype plasticity; Liver; Adipose tissue; Metabolism; Maternal protein undernutrition
Core Tip	Perinatal exposure to a poor nutritional environment predisposes to metabolic disease. Here, the expression of metabolism-related genes in adipose tissue and liver was investigated. We evaluated the alterations in gene expression of glycolytic/Krebs cycle genes, adipogenic and lipolitic genes in adipose tissue of offspring rats at 30/90 d of age, exposed to maternal low-protein diet throughout gestation/lactation. We also evaluated expression of liver transcription factors and gluconeogenic genes. Persistent gene alterations were observed, that may account for the metabolic adaptations in response to maternal low-protein diet, highlighting the occurrence of persistent transcriptional defects as a consequence of perinatal malnutrition.
Citation	de Oliveira Lira A, de Brito Alves JL, Pinheiro Fernandes M, Vasconcelos D, Santana DF, da Costa-Silva JH, Morio B, Góis Leandro C, Pirola L. Maternal low protein diet induces persistent expression changes in metabolic genes in male rats. World J Diabetes 2020; 11(5): 182-192

Received	2019-12-18 13:15
Peer-Review Started	2019-12-12 14:11
To Make the First Decision
Return for Revision	2020-01-06 22:07
Revised	2020-03-16 20:49
Second Decision	2020-03-30 15:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-03-30 21:09
Articles in Press	2020-03-30 21:09
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-04-07 22:40
Typeset the Manuscript	2020-05-09 03:35

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com