Publication Name	World Journal of Gastroenterology
Manuscript ID	53304
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Hepatic microenvironment underlies fibrosis in chronic hepatitis B patients
Manuscript Source	Invited Manuscript
All Author List	Qun-Yan Yao, Ya-Dong Feng, Pei Han, Feng Yang and Guang-Qi Song
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation for the Youth of China 81500460 National Natural Science Foundation for the Youth of China 81700550
Corresponding Author	Guang-Qi Song, MD, PhD, Professor, Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Xuhui District, Shanghai 200032, China. song_guangqi@fudan.edu.cn
Key Words	Microenvironment; Liver fibrosis; Chronic hepatitis B; Human stellate cell; Interleukin-1β;
Core Tip	We partially profiled the microenvironment factors in hepatitis B virus (HBV) infected patients. In vitro, we stimulated hepatic stellate cell line LX-2 with different growth factors, cytokines or the combination. Our study demonstrated that the hepatic microenvironment involving crosstalk of profibrotic and proinflammatory factors in the hepatitis patients underlies fibrosis. Treating the stellate cells by combining interleukin-1β and transforming growth factor-β1 may serve as an in vitro model for fibrotic HBV infected patients better recapitulating the liver microenvironment.
Citation	Yao QY, Feng YD, Han P, Yang F, Song GQ. Hepatic microenvironment underlies fibrosis in chronic hepatitis B patients. World J Gastroenterol 2020; 26(27): 3917-3928

Received	2019-12-15 06:14
Peer-Review Started	2019-12-15 06:14
To Make the First Decision
Return for Revision	2020-04-01 03:32
Revised	2020-05-15 13:05
Second Decision	2020-06-30 09:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-06-30 19:33
Articles in Press	2020-06-30 19:33
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-07-07 03:30
Typeset the Manuscript	2020-07-20 08:33

ISSN	1007-9327 (print) and 2219-2840 (online)
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