Publication Name	World Journal of Gastroenterology
Manuscript ID	53392
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	PTEN-induced kinase 1-induced dynamin-related protein 1 Ser637 phosphorylation reduces mitochondrial fission and protects against intestina ischemia reperfusion injury
Manuscript Source	Unsolicited Manuscript
All Author List	Wasim Qasim, Yang Li, Rui-Min Sun, Dong-Cheng Feng, Zhan-Yu Wang, De-Shun Liu, Ji-Hong Yao and Xiao-Feng Tian
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81679154 National Natural Science Foundation of China 81871547
Corresponding Author	Xiao-Feng Tian, MD, PhD, Director, Professor, Surgeon, Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, 467 Zhongshan Road, Shahekou District, Dalian 116023, Liaoning Province, China. txfdl@dmu.edu.cn
Key Words	Intestinal ischemia reperfusion injury; Mitochondrial fission; PTEN-induced putative kinase 1; Dynamin-related protein 1 ser637; Phosphorylation; Apoptosis
Core Tip	PTEN induced kinase 1 (PINK1) is a kind of mitochondrial serine/threonine-protein kinase, which regulates mitochondrial homeostasis through regulating the phosphorylation of target proteins. Depletion of PINK1 has been proved that associated with mitochondrial fragmentation and apoptosis in ischemic model. However, the underlying mechanism has not been clarified. By generating intestinal ischemia reperfusion model in mice and hypoxia/reoxygenation model in Caco-2 cells, we revealed that PINK1 inhibits mitochondrial fission and apoptosis via phosphorylating dynamin-related protein 1 on Ser637. The PINK1/dynamin-related protein 1 pathway may provide a potential target in intestinal ischemia reperfusion injury treatment.
Citation	Qasim W, Li Y, Sun RM, Feng DC, Wang ZY, Liu DS, Yao JH, Tian XF. PTEN-induced kinase 1-induced dynamin-related protein 1 Ser637 phosphorylation reduces mitochondrial fission and protects against intestinal ischemia reperfusion injury. World J Gastroenterol 2020; 26(15): 1758-1774

Received	2019-12-28 10:10
Peer-Review Started	2019-12-28 10:11
To Make the First Decision
Return for Revision	2020-01-11 22:51
Revised	2020-03-17 14:08
Second Decision	2020-03-26 10:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-03-26 21:01
Articles in Press	2020-03-26 21:01
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-04-02 01:49
Typeset the Manuscript	2020-04-17 02:17

ISSN	1007-9327 (print) and 2219-2840 (online)
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