Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	53482
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Efficacy of mesenchymal stem cells in the treatment of gastrointestinal malignancies
Manuscript Source	Invited Manuscript
All Author List	Jian-Nan Li, Wei Li, Lan-Qing Cao, Ning Liu and Kai Zhang
Funding Agency and Grant Number
Corresponding Author	Kai Zhang, MD, PhD, Chief Doctor, Professor, Department of General Surgery, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, Jilin Province, China. zhang_kai@jlu.edu.cn
Key Words	Mesenchymal stem cells; Gastrointestinal malignancies; Gastric cancer; Hepatoma; Pancreatic cancer; Colorectal cancer
Core Tip	Mesenchymal stem cells (MSCs) possess immune privileged nature, tumor homing feature, and multi-lineage differentiation ability. Gastrointestinal (GI) malignancies are the major causes of cancer-related death worldwide. The interactions of MSCs and GI cancer cells in specific conditions have attracted more and more attentions. In this review, we would like to introduce the characteristics of MSCs and analyse the effects of MSCs on GI malignancies. In addition, we also provide our perspectives on the reason why MSCs may play different roles in GI malignancies and further research directions to increase the treatment efficacy of MSCs on GI malignancies.
Citation	Li JN, Li W, Cao LQ, Liu N, Zhang K. Efficacy of mesenchymal stem cells in the treatment of gastrointestinal malignancies. World J Gastrointest Oncol 2020; 12(4): 365-382

Received	2020-01-02 13:47
Peer-Review Started	2020-01-02 13:47
To Make the First Decision	2020-02-24 12:40
Return for Revision	2020-02-27 10:58
Revised	2020-03-03 09:38
Second Decision	2020-03-25 09:12
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-03-26 13:21
Articles in Press	2020-03-26 13:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-04-14 01:30

ISSN	1948-5204 (online)
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