Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	53498
Country	Spain

Category	Microbiology
Manuscript Type	Retrospective Cohort Study
Article Title	Evaluation of bacterial biomarkers to aid in challenging inflammatory bowel diseases diagnostics and subtype classification
Manuscript Source	Invited Manuscript
All Author List	Mireia Lopez-Siles, Xavier Aldeguer, Miriam Sabat-Mir, Mariona Serra-Pagès, Sylvia H Duncan, Harry J Flint, L Jesús Garcia-Gil and Margarita Martinez-Medina
Funding Agency and Grant Number	Funding Agency Grant Number Spanish Ministry of Education and Science SAF2010-15896 Spanish Ministry of Education and Science SAF2013-43284-P Spanish Ministry of Education and Science SAF2017-82261-P
Corresponding Author	Margarita Martinez-Medina, PhD, Associate Professor, Laboratory of Molecular Microbiology, Biology Department, Universitat de Girona, Carrer de Maria Aurèlia Capmany, 40, Girona 17003, Spain. marga.martinez@udg.edu
Key Words	Crohn’s disease; Ulcerative colitis; Inflammatory bowel disease; Diagnostic tests; Faecalibacterium prausnitzii; Escherichia coli
Core Tip	This manuscript evaluates the usefulness of new indexes calculated from the quantification of Faecalibacterium prausnitzii, its phylogroups, and Escherichia coli as biomarkers to assist in challenges of inflammatory bowel disease diagnostics. Firstly, discrimination between inflammatory bowel disease and other intestinal disorders was tested. We present indices to distinguish colorectal cancer from inflammatory bowel disease, especially from subjects with ulcerative colitis. This is of significance given the association between chronic inflammation and the risk of colorectal cancer. In contrast, the proposed indices featured limited performance for discriminating inflammatory bowel disease from irritable bowel syndrome. Secondly, we approach if these biomarkers would be useful to discriminate within inflammatory bowel disease subtypes. We show here good biomarkers to differentiate inflammatory bowel disease subtypes of shared disease location, which may assist in monitoring the risk of progression of the inflamed area. Their application in non-invasive faecal samples is also demonstrated.
Citation	Lopez-Siles M, Aldeguer X, Sabat-Mir M, Serra-Pagès M, Duncan SH, Flint HJ, Garcia-Gil LJ, Martinez-Medina M. Evaluation of bacterial biomarkers to aid in challenging inflammatory bowel diseases diagnostics and subtype classification. World J Gastrointest Pathophysiol 2020; 11(3): 64-77

Received	2019-12-30 14:52
Peer-Review Started	2019-12-30 14:53
To Make the First Decision	2020-02-11 00:30
Return for Revision	2020-02-13 05:21
Revised	2020-02-27 15:15
Second Decision	2020-03-30 14:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-03-30 20:59
Articles in Press	2020-03-30 20:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-05-09 10:30

ISSN	2150-5330 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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