Publication Name	World Journal of Gastroenterology
Manuscript ID	53714
Country	United Kingdom

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Refractory very early-onset inflammatory bowel disease associated with cytosolic isoleucyl-tRNA synthetase deficiency: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Andrew Fagbemi, William G Newman, Stuart G Tangye, Stephen M Hughes, Edmund Cheesman and Peter D Arkwright
Funding Agency and Grant Number
Corresponding Author	Peter D Arkwright, MD, PhD, Senior Lecturer, Department of Paediatric Allergy and Immunology, Royal Manchester Children’s Hospital, Oxford Road, Manchester M139WL, United Kingdom. peter.arkwright@manchester.ac.uk
Key Words	Inflammatory bowel disease; Hepatitis; Gene; Cytosolic isoleucine tRNA synthase; ;
Core Tip	Consider cytosolic isoleucyl-tRNA synthetase in children presenting with neonatal hepatitis and refractory very early-onset inflammatory bowel disease. This case report provides evidence for a novel monogenic cause of inflammatory bowel disease that should be considered, particularly in patients with very early-onset, poor response to treatment and a history of neonatal hepatitis.
Citation	Fagbemi A, Newman WG, Tangye SG, Hughes SM, Cheesman E, Arkwright PD. Refractory very early-onset inflammatory bowel disease associated with cytosolic isoleucyl-tRNA synthetase deficiency: A case report. World J Gastroenterol 2020; 26(15): 1841-1846

Received	2020-01-06 18:03
Peer-Review Started	2020-01-06 18:15
To Make the First Decision
Return for Revision	2020-01-19 01:59
Revised	2020-03-26 17:27
Second Decision	2020-03-30 10:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-03-31 19:09
Articles in Press	2020-03-31 19:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-04-20 00:42

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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