Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	53783
Country	China

Category	Surgery
Manuscript Type	Retrospective Cohort Study
Article Title	Mammalian target of rapamycin inhibitors after post-transplant hepatocellular carcinoma recurrence: Is it too late?
Manuscript Source	Invited Manuscript
All Author List	Kin Pan Au and Kenneth Siu Ho Chok
Funding Agency and Grant Number
Corresponding Author	Kenneth Siu Ho Chok, FACS, FRCS (Ed), MBBS, Associate Professor, Department of Surgery and State Key Laboratory for Liver Research, The University of Hong Kong, 102 Pok Fu Lam Road, Hong Kong 999077, China. chok6275@hku.hk
Key Words	Mammalian target of rapamycin inhibitor; Hepatocellular carcinoma; Recurrence; Liver transplant; Survival; Outcomes
Core Tip	Mammalian target of rapamycin (mTOR) inhibitors have been shown to reduce the risk of tumour recurrence after liver transplantation for hepatocellular carcinoma (HCC). However, its role in established post-transplant HCC recurrence is uncertain. A retrospective study of 143 patients who developed HCC recurrence after liver transplantation was performed. Seventy-nine (55%) patients received mTOR inhibitor-based immunosuppressive regime while 64 (45%) of them did not. The median post-recurrence survival was 21.0 ± 4.1 mo in mTOR inhibitor group and 11.2 ± 2.5 mo in the control group. Multivariate cox regression analysis confirmed mTOR inhibitor was independently associated with improved post-recurrence survival (P = 0.04, OR 0.482, 95%CI: 0.241-0.966).
Citation	Au KP, Chok KSH. Mammalian target of rapamycin inhibitors after post-transplant hepatocellular carcinoma recurrence: Is it too late? World J Gastrointest Surg 2020; 12(4): 149-158

Received	2019-12-30 10:53
Peer-Review Started	2019-12-30 10:55
To Make the First Decision
Return for Revision	2020-01-28 21:53
Revised	2020-03-21 14:56
Second Decision	2020-03-25 06:19
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-03-26 13:24
Articles in Press	2020-03-26 13:24
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-03-31 01:18
Typeset the Manuscript	2020-04-16 12:28

ISSN	1948-9366 (online)
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