Publication Name	World Journal of Orthopedics
Manuscript ID	54156
Country	United States

Category	Orthopedics
Manuscript Type	Systematic Reviews
Article Title	Oxysterols as promising small molecules for bone tissue engineering: Systematic review
Manuscript Source	Unsolicited Manuscript
All Author List	Ethan Cottrill, Julianna Lazzari, Zach Pennington, Jeff Ehresman, Andrew Schilling, Naomi Dirckx, Nicholas Theodore, Daniel Sciubba and Timothy Witham
Funding Agency and Grant Number
Corresponding Author	Ethan Cottrill, MSc, Research Scientist, Department of Neurosurgery, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, United States. ecottri1@jhmi.edu
Key Words	Oxysterol; Bone tissue engineering; Critical-sized defect; Biomaterial; Orthopaedic surgery; Systematic review
Core Tip	Here we present the first systematic review evaluating the utility of oxysterols for bone tissue engineering. Thirteen preclinical studies examining seven unique oxysterols were evaluated; all examined compounds were found to have statistically significant in vivo osteoinductive properties, with some showing dose-dependent effects. Importantly, eight studies found oxysterols to have similar osteoinductive properties to rhBMP-2 in treated animals. These effects are thought to occur through direct activation of Smoothened in the Hedgehog signaling pathway. Future clinical work is necessary to determine the exact therapeutic utility of these molecules in orthopaedic surgery patients.
Citation	Cottrill E, Lazzari J, Pennington Z, Ehresman J, Schilling A, Dirckx N, Theodore N, Sciubba D, Witham T. Oxysterols as promising small molecules for bone tissue engineering: Systematic review. World J Orthop 2020; 11(7): 328-344

Received	2020-01-14 21:18
Peer-Review Started	2020-01-14 21:18
To Make the First Decision
Return for Revision	2020-04-22 21:48
Revised	2020-05-08 15:18
Second Decision	2020-06-29 09:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-07-01 22:29
Articles in Press	2020-07-01 22:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-07-10 10:20

ISSN	2218-5836 (online)
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