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Publication Name World Journal of Clinical Oncology
Manuscript ID 54280
Country/Territory India
Category Oncology
Manuscript Type Observational Study
Article Title Mutational analysis of Ras hotspots in patients with urothelial carcinoma of the bladder
Manuscript Source Invited Manuscript
All Author List Kiran Tripathi, Apul Goel, Atin Singhai and Minal Garg
Funding Agency and Grant Number
Funding Agency Grant Number
Department of Science and Technology, Govt. of India SR/SO/HS-0113/2010
University Grants Commission (UGC), Govt. of India 22/12/2013(ii)EU-V
Corresponding Author Minal Garg, MSc, PhD, Assistant Professor, Doctor, Department of Biochemistry, University of Lucknow, University Road, Lucknow 226007, India. minal14@yahoo.com
Key Words Coding exons; Oncogenic activation; Polymerase chain reaction - restriction fragment length polymorphism; Point mutations; Ras genes; Urothelial carcinoma of bladder
Core Tip Mutant Ras is shown to be associated with drug resistance, enhanced metastasis and shorter survival of patients. Owing to reported heterogeneity among distribution of the most frequent mutations in Ras isoforms in different patients’ populations with urothelial carcinoma of bladder, it is necessary to examine the patients for Ras mutations in order to prognose disease clinical outcome. Our findings on the lack of Ras mutations could be explained on the basis of different etiological mechanisms involved in tumor development, inherent genetic susceptibility, tissue specificity or alternative Ras dysfunction including gene amplification or overexpression in a given cohort of patients.
Citation Tripathi K, Goel A, Singhai A, Garg M. Mutational analysis of Ras hotspots in patients with urothelial carcinoma of the bladder. World J Clin Oncol 2020; 11(8): 614-628
Received
2020-01-20 12:43
Peer-Review Started
2020-01-20 12:43
To Make the First Decision
Return for Revision
2020-04-22 09:10
Revised
2020-05-21 13:01
Second Decision
2020-07-01 10:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-07-01 22:33
Articles in Press
2020-07-01 22:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-07-13 06:46
Typeset the Manuscript
2020-07-28 07:58
ISSN 2218-4333 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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