Publication Name	World Journal of Gastroenterology
Manuscript ID	54734
Country	Italy

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Spontaneous porto-systemic shunts in liver cirrhosis: Clinical and therapeutical aspects
Manuscript Source	Unsolicited Manuscript
All Author List	Silvia Nardelli, Oliviero Riggio, Stefania Gioia, Marta Puzzono, Giuseppe Pelle and Lorenzo Ridola
Funding Agency and Grant Number
Corresponding Author	Lorenzo Ridola, MD, PhD, Doctor, Department of Translational and Precision Medicine, “Sapienza” University of Rome, viale dell’Università 37, Rome 00185, Italy. lorenzo.ridola@uniroma1.it
Key Words	Porto-systemic shunts; Liver cirrhosis; Variceal bleeding; Hepatic encephalopathy; Portal vein thrombosis; Porto-systemic shunt syndrome
Core Tip	Liver cirrhosis is characterized by a progressive increase in portal hypertension and the consequent formation of porto-systemic shunts, that act as “release valves” to reduce the portal pressure, but also act as bypasses to normal liver flow. As the shunt becomes large enough, the complications appear including hepatic encephalopathy, variceal bleeding, portal vein thrombosis and the deterioration of liver function.
Citation	Nardelli S, Riggio O, Gioia S, Puzzono M, Pelle G, Ridola L. Spontaneous porto-systemic shunts in liver cirrhosis: Clinical and therapeutical aspects. World J Gastroenterol 2020; 26(15): 1726-1732

Received	2020-02-15 18:54
Peer-Review Started	2020-02-15 18:55
To Make the First Decision
Return for Revision	2020-03-15 03:57
Revised	2020-03-21 10:34
Second Decision	2020-03-26 09:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-03-26 20:58
Articles in Press	2020-03-26 20:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-04-15 13:09

ISSN	1007-9327 (print) and 2219-2840 (online)
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