Publication Name	World Journal of Hepatology
Manuscript ID	54801
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Geoepidemiologic variation in outcomes of primary sclerosing cholangitis
Manuscript Source	Invited Manuscript
All Author List	Tej I Mehta, Simcha Weissman, Brian M Fung and James H Tabibian
Funding Agency and Grant Number
Corresponding Author	James H Tabibian, FACP, MD, PhD, Associate Professor, Division of Gastroenterology, Department of Medicine, UCLA-Olive View Medical Center, Clinical Health Sciences David Geffen School of Medicine at UCLA, 14445 Olive View Dr 2B-182, Sylmar, CA 91342, United States. jtabibian@dhs.lacounty.gov
Key Words	Cholangiocarcinoma; Inflammatory bowel disease; Liver transplantation; Geography; Biliary tract; Autoimmune
Core Tip	There appears to be considerable geoepidemiologic variation in the outcomes of primary sclerosing cholangitis (PSC). Median liver transplantation-free survival in adults with PSC ranges from 14 to 21 years, depending on geographic region. Post-liver transplantation survival for PSC in North America and Europe appears to be nearly twice that found in Asia. The overall average risk of cholangiocarcinoma among patients with PSC is approximately 400 times that of the general population, occurring in roughly 7%-9% of all patients with PSC. However, these rates vary from region to region, with East Asia having rates roughly three-times higher compared to other regions. Studies from North America, Europe, and Oceania generally report worse clinical outcomes for patients with PSC-inflammatory bowel disease compared to patients with only PSC or inflammatory bowel disease; however, this association is less prominent in studies from Asia.
Citation	Mehta TI, Weissman S, Fung BM, Tabibian JH. Geoepidemiologic variation in outcomes of primary sclerosing cholangitis. World J Hepatol 2020; 12(4): 116-124

Received	2020-02-19 13:19
Peer-Review Started	2020-02-19 13:21
To Make the First Decision
Return for Revision	2020-03-15 01:33
Revised	2020-03-15 23:53
Second Decision	2020-03-20 15:03
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-03-24 13:07
Articles in Press	2020-03-24 13:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-04-15 12:38

ISSN	1948-5182 (online)
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