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Publication Name World Journal of Gastroenterology
Manuscript ID 54957
Country/Territory Türkiye
Category Pathology
Manuscript Type Retrospective Study
Article Title Expression of Notch pathway components (Numb, Itch, and Siah-1) in colorectal tumors: A clinicopathological study
Manuscript Source Invited Manuscript
All Author List Sinem Cil Gonulcu, Betul Unal, Ibrahim Cumhur Bassorgun, Mualla Ozcan, Hasan Senol Coskun and Gulsum Ozlem Elpek
Funding Agency and Grant Number
Funding Agency Grant Number
Akdeniz University Research Foundation 2017.04.0103.020
Corresponding Author Gulsum Ozlem Elpek, MD, Professor, Department of Pathology, Akdeniz University Medical School, Dumlupınar Bulvarı, Antalya 07070, Türkiye. elpek@akdeniz.edu.tr
Key Words Colorectal adenomas; Colorectal cancer; Notch-1; Numb; Itch; Siah-1
Core Tip This report describes a preliminary study to investigate Numb, Itch, and Siah-1 expression in colorectal tumors and to evaluate their relationship with Notch-1 expression and their roles in oncogenesis and prognosis. Our findings confirm the role of Notch-1 in colorectal carcinoma (CRC) and emphasize that loss of Numb, Itch, and Siah-1 expression is associated with carcinogenesis. Our data also indicate that Numb, Itch, and Siah-1 might be involved in the Notch-1 signaling pathway during CRC progression. Accordingly, these three proteins might be key in possible therapies targeting Notch-1 to treat colorectal carcinoma.
Citation Gonulcu SC, Unal B, Bassorgun IC, Ozcan M, Coskun HS, Elpek GO. Expression of Notch pathway components (Numb, Itch, and Siah-1) in colorectal tumors: A clinicopathological study. World J Gastroenterol 2020; 26(26): 3814-3833
Received
2020-02-26 11:29
Peer-Review Started
2020-02-26 11:30
To Make the First Decision
Return for Revision
2020-03-18 03:45
Revised
2020-05-18 03:26
Second Decision
2020-06-24 08:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-06-25 04:53
Articles in Press
2020-06-25 04:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-07-14 01:33
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
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