Publication Name	World Journal of Psychiatry
Manuscript ID	55073
Country	Mexico

Category	Psychiatry
Manuscript Type	Basic Study
Article Title	Serum levels of chemokines in adolescents with major depression treated with fluoxetine
Manuscript Source	Invited Manuscript
All Author List	Francisco Rafael de la Peña, Carlos Cruz-Fuentes, Lino Palacios, Manuel Iván Girón-Pérez, Emilio Medina-Rivero, Maria Dolores Ponce-Regalado, Samantha Alvarez-Herrera, Gilberto Pérez-Sánchez, Enrique Becerril-Villanueva, José Luis Maldonado-García, María C Jiménez-Martínez and Lenin Pavón
Funding Agency and Grant Number	Funding Agency Grant Number Secretaria de Ciencia, Tecnología e Innovación 0048/2014
Corresponding Author	Lenin Pavón, PhD, Professor, Laboratory of Psychoimmunology, National Institute of Psychiatry, “Ramón de la Fuente”, Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Mexico City 14070, Mexico. lkuriaki@imp.edu.mx
Key Words	Adolescents; Major depression; Chemokine; Fluoxetine; Interferon gamma-induced protein-10;
Core Tip	Major depressive disorder affects 350 million of persons, approximately 6% of them are adolescents. This study aimed to determine the differences in circulatory levels of chemokines like eotaxin, interleukin-8, induced protein 10, monocyte chemoattractant protein-1, macrophage inflammatory protein (MIP)-1α and MIP-1β in healthy volunteers and adolescents with major depression and assess the changes induced by antidepressants consume during 8 wk of clinical follow-up, which is the minimum time to observe the therapeutic efficacy of selective serotonin reuptake inhibitors, like fluoxetine in adolescents. Our results showed a significant elevation in serum chemokine levels in adolescents with major depression despite treatment with fluoxetine and an improvement in scores of Hamilton depresión rating scale.
Citation	de la Peña FR, Cruz-Fuentes C, Palacios L, Girón-Pérez MI, Medina-Rivero E, Ponce-Regalado MD, Alvarez-Herrera S, Pérez-Sánchez G, Becerril-Villanueva E, Maldonado-García JL, Jiménez-Martínez MDC, Pavón L. Serum levels of chemokines in adolescents with major depression treated with fluoxetine. World J Psychiatr 2020; 10(8): 175-186

Received	2020-02-29 05:51
Peer-Review Started	2020-02-29 05:52
To Make the First Decision
Return for Revision	2020-04-29 21:39
Revised	2020-05-31 12:19
Second Decision	2020-06-24 08:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-06-27 20:53
Articles in Press	2020-06-27 20:53
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-07-05 02:24
Typeset the Manuscript	2020-08-12 02:32

ISSN	2220-3206 (online)
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