Publication Name	World Journal of Clinical Oncology
Manuscript ID	55398
Country	United States

Category	Genetics & Heredity
Manuscript Type	Review
Article Title	Powerful quantifiers for cancer transcriptomics
Manuscript Source	Invited Manuscript
All Author List	Dumitru Andrei Iacobas
Funding Agency and Grant Number
Corresponding Author	Dumitru Andrei Iacobas, MSc, PhD, Director, Professor, Personalized Genomics Laboratory, CRI Center for Computational Systems Biology, Roy G Perry College of Engineering, Prairie View A&M University, Prairie View, TX 77446, United States. daiacobas@pvamu.edu
Key Words	Cancer biomarkers; Cancer nodule; Gene therapy; Kidney cancer; Prostate cancer; RNA gene
Core Tip	The Genomic Fabric Paradigm was developed as a holistic alternative to the biomarker approach of cancer transcriptomics. The genomic fabric of a functional pathway is the transcriptome associated with the most interconnected and stably expressed gene network responsible for that pathway. We present the associated analytical tools to characterize the topology, remodeling during cancer progression and in response to a therapy, and interplay of the genomic fabrics and identify the most legitimate targets in cancer gene therapy. The analyses are illustrated with examples from our transcriptomic studies on human cancer tissues and cell lines.
Citation	Iacobas DA. Powerful quantifiers for cancer transcriptomics. World J Clin Oncol 2020; 11(9): 679-704

Received	2020-03-15 19:50
Peer-Review Started	2020-03-17 00:24
To Make the First Decision
Return for Revision	2020-04-18 21:12
Revised	2020-06-06 16:00
Second Decision	2020-07-01 10:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-07-01 22:42
Articles in Press	2020-07-01 22:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-08-31 03:59

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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