Publication Name	World Journal of Hepatology
Manuscript ID	55536
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Update on diagnosis and management of sepsis in cirrhosis: Current advances
Manuscript Source	Invited Manuscript
All Author List	Cyriac Abby Philips, Rizwan Ahamed, Sasidharan Rajesh, Tom George, Meera Mohanan and Philip Augustine
Funding Agency and Grant Number
Corresponding Author	Cyriac Abby Philips, MBBS, MD, Associate Chief Physician, The Liver Unit and Monarch Liver Lab, Cochin Gastroenterology Group, Ernakulam Medical Center, 10th Floor, E.M.C Hospital, NH-Bypass, Palarivattom, Kochi 682028, Kerala, India. abbyphilips@gmail.com
Key Words	Portal hypertension; Sequential organ failure assessment; Acute on chronic liver failure; Predisposition insult response organ-dysfunction model; Intensive care unit; Shock
Core Tip	Advances in understanding sepsis have led to an uncomplicated and robust definition with prognostic importance. This has seen an emergence in redefining the clinical protocols for early and aggressive management of sepsis at hour one of patient presentation, identification of a novel combination of biomarkers and addressing antimicrobial resistance and identification of adjuvant therapies through deep data mining, metagenomics and machine learning-based tools for improving clinical outcomes. These advances have the potential to be extrapolated and studied in patients with cirrhosis and sepsis to improve notable catastrophic clinical outcomes seen in this unique and challenging to treat patient population.
Citation	Philips CA, Ahamed R, Rajesh S, George T, Mohanan M, Augustine P. Update on diagnosis and management of sepsis in cirrhosis: Current advances. World J Hepatol 2020; 12(8): 451-474

Received	2020-03-22 08:55
Peer-Review Started	2020-03-22 08:58
To Make the First Decision
Return for Revision	2020-04-12 22:40
Revised	2020-05-28 17:17
Second Decision	2020-06-23 08:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-06-27 20:49
Articles in Press	2020-06-27 20:49
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-07-03 03:42
Typeset the Manuscript	2020-08-23 03:35

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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