Publication Name	World Journal of Gastroenterology
Manuscript ID	55692
Country	China

Category	Oncology
Manuscript Type	Randomized Controlled Trial
Article Title	Transarterial chemoembolization with hepatic arterial infusion chemotherapy plus S-1 for hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Jian-Hai Guo, Shao-Xing Liu, Song Gao, Fu-Xin Kou, Xin Zhang, Di Wu, Xiao-Ting Li, Hui Chen, Xiao-Dong Wang, Peng Liu, Peng-Jun Zhang, Hai-Feng Xu, Guang Cao, Lin-Zhong Zhu, Ren-Jie Yang and Xu Zhu
Funding Agency and Grant Number	Funding Agency Grant Number Sanofi
Corresponding Author	Xu Zhu, MD, Chief Doctor, Professor, Department of Interventional Therapy, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, No. 52, Fucheng Road, Haidian District, Beijing 100142, China. drzhuxu@163.com
Key Words	Hepatocellular carcinoma; Advanced; Hepatic arterial infusion chemotherapy; Transarterial chemoembolization; Prognosis; Efficacy
Core Tip	This randomized controlled trial showed that the addition of oral S-1 (a composite preparation of a 5-fluorouracil prodrug) to transarterial chemoembolization (TACE) followed by hepatic arterial infusion chemotherapy (HAIC) with oxaliplatin did not lengthen the survival times of patients with advanced hepatocellular carcinoma (HCC) complicating portal vein invasion or extrahepatic metastasis, although it did lead appear to have moderately better anti-tumor activity. TACE combined with HAIC was an effective and safe treatment for patients with advanced HCC with portal vein invasion or extrahepatic metastasis.
Citation	Guo JH, Liu SX, Gao S, Kou FX, Zhang X, Wu D, Li XT, Chen H, Wang XD, Liu P, Zhang PJ, Xu HF, Cao G, Zhu LZ, Yang RJ, Zhu X. Transarterial chemoembolization with hepatic arterial infusion chemotherapy plus S-1 for hepatocellular carcinoma. World J Gastroenterol 2020; 26(27): 3975-3988

Received	2020-03-29 13:54
Peer-Review Started	2020-03-29 14:04
To Make the First Decision
Return for Revision	2020-04-25 04:08
Revised	2020-05-07 00:52
Second Decision	2020-07-01 10:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-07-04 04:04
Articles in Press	2020-07-04 04:04
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-07-07 22:23
Typeset the Manuscript	2020-07-20 08:31

ISSN	1007-9327 (print) and 2219-2840 (online)
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