BPG is committed to discovery and dissemination of knowledge
Articles in Press
9/25/2020 5:32:18 AM | Browse: 39 | Download: 31
Publication Name World Journal of Gastroenterology
Manuscript ID 56685
Country/Territory Canada
Category Oncology
Manuscript Type Retrospective Study
Article Title Real-world treatment attrition rates in advanced esophagogastric cancer
Manuscript Source Unsolicited Manuscript
All Author List Erica S Tsang, Howard J Lim, Daniel J Renouf, Janine M Davies, Jonathan M Loree and Sharlene Gill
Funding Agency and Grant Number
Corresponding Author Sharlene Gill, MD, Doctor, Medicine, BC Cancer, 600 West 10th Avenue, Vancouver V5Z 4E6, Canada. sgill@bccancer.bc.ca
Key Words Esophagogastric cancer; Gastric cancer; Treatment attrition; Systemic therapy; Treatment outcomes; Real-world evidence
Core Tip Despite the availability of later lines of therapy for esophagogastric cancer (EGC), there remains limited real-world data about the treatment attrition rates between lines of therapy. In this population-based analysis, we characterize the use and treatment attrition rates for patients with advanced EGC. Among 245 patients, there was a high level of treatment attrition, with 50% receiving one line of therapy, 34% receiving two lines, and 14% receiving three-lines. Improved survival was associated with better baseline Eastern Cooperative Oncology Group and increased lines of therapy. This real-world analysis demonstrating such steep attrition rates highlights the unmet need for more efficacious early-line treatment options.
Citation Tsang ES, Lim HJ, Renouf DJ, Davies JM, Loree JM, Gill S. Real-world treatment attrition rates in advanced esophagogastric cancer. World J Gastroenterol 2020; 26(39): 6027-6036
Received
2020-05-10 05:20
Peer-Review Started
2020-05-10 05:21
To Make the First Decision
Return for Revision
2020-06-13 02:10
Revised
2020-06-24 17:39
Second Decision
2020-09-24 10:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-09-25 05:32
Articles in Press
2020-09-25 05:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-10-20 11:40
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com