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Articles in Press
9/25/2020 7:22:33 PM | Browse: 115 | Download: 312
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Effect of conditioned medium from neural stem cells on glioma progression and its protein expression profile analysis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Gui-Long Zhang, Cheng Qian, Shi-Zhen Zhang, Yong-Hua Tuo, Bai-Yun Zeng, Yun-Xiang Ji and Ye-Zhong Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| China Postdoctoral Science Foundation |
2019TQ0071 |
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| Corresponding Author |
Ye-Zhong Wang, MD, PhD, Chairman, Chief Doctor, Professor, Department of Neurosurgery, The Second Affiliated Hospital of Guangzhou Medical University, No. 250 Changgang, Haizhu District, Guangzhou 510260, Guangdong Province, China. wangyezhong@gzhmu.edu.cn |
| Key Words |
Neural stem cells; Glioma; Conditioned medium; NCAN; Hypoxia; Protein |
| Core Tip |
The cell communications or crosstalk between glioma cells and non-glioma cells in the tumor microenvironment plays dominant roles in tumor therapy. The subventricular zone (SVZ) Neural stem cells (NSCs) have been shown to be closely associated with glioma progression and recurrence. Interestingly, the conditioned medium (CM) from SVZ NSCs significantly promoted glioma cell proliferation and invasion, with oxygen glucose deprivation-NSC-CM showing enhanced effects. Furthermore, the secreted protein NCAN presented in oxygen glucose deprivation-NSC-CM played important roles in the progression of glioma cells mainly via Rho/Rho-associated protein kinase pathway. Overall, this study provided important insights into the potential therapeutic application of NCAN derived from SVZ NSCs in the treatment of glioma. |
| Citation |
Zhang GL, Qian C, Zhang SZ, Tuo YH, Zeng BY, Ji YX, Wang YZ. Effect of conditioned medium from neural stem cells on glioma progression and its protein expression profile analysis. World J Stem Cells 2020; 12(11): 1396-1409 |
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Received |
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2020-06-01 06:45 |
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Peer-Review Started |
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2020-06-01 06:46 |
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To Make the First Decision |
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Return for Revision |
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2020-08-22 21:12 |
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Revised |
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2020-09-04 10:25 |
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Second Decision |
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2020-09-25 09:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2020-09-25 19:22 |
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Articles in Press |
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2020-09-25 19:22 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-10-16 00:16 |
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Typeset the Manuscript |
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2020-11-20 00:27 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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