BPG is committed to discovery and dissemination of knowledge
Articles in Press
9/25/2020 7:02:03 PM | Browse: 128 | Download: 278
Publication Name World Journal of Stem Cells
Manuscript ID 57740
Country/Territory Canada
Category Cell Biology
Manuscript Type Review
Article Title Novel insights for improving the therapeutic safety and efficiency of mesenchymal stromal cells
Manuscript Source Invited Manuscript
All Author List Mehdi Najar, Johanne Martel-Pelletier, Jean Pierre Pelletier and Hassan Fahmi
Funding Agency and Grant Number
Funding Agency Grant Number
La Chaire en Arthrose de l’Université de Montréal
Corresponding Author Mehdi Najar, PhD, Academic Fellow, Department of Medicine, University of Montreal, Osteoarthritis Research Unit, University of Montreal Hospital Research Center (CRCHUM), 900 Saint-Denis Street, R Tower, 11th floor, Montreal H2X 0A9, QC, Canada. mnajar@ulb.ac.be
Key Words Cell-therapy; Mesenchymal stromal cells; Safety; Extracellular vesicles; Efficiency; Preconditioning
Core Tip Mesenchymal stromal cells (MSCs) have a strong capacity to regenerate injured tissues by displaying trophic and immunomodulatory functions. The tissue environment plays a significant role during the reparative process of MSCs. Preconditioning of MSCs with a specific signal promotes the adequate response. As the therapeutic functions of MSCs are mainly linked to their secretome, the use of extracellular vesicles as an acellular tool is strongly recommended. Thus, new insights on the properties of MSCs as well as their mechanisms of actions will help to develop a safe and efficient therapeutic strategy.
Citation Najar M, Martel-Pelletier J, Pelletier JP, Fahmi H. Novel insights for improving the therapeutic safety and efficiency of mesenchymal stromal cells. World J Stem Cells 2020; 12(12): 1474-1491
Received
2020-06-23 08:14
Peer-Review Started
2020-06-23 08:15
To Make the First Decision
Return for Revision
2020-07-30 23:02
Revised
2020-08-13 07:20
Second Decision
2020-09-25 09:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-09-25 19:02
Articles in Press
2020-09-25 19:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-12-24 00:44
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com