Publication Name	World Journal of Gastroenterology
Manuscript ID	57902
Country	Japan

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Relationships of early esophageal cancer with human papillomavirus and alcohol metabolism
Manuscript Source	Unsolicited Manuscript
All Author List	Masaki Inoue, Yuichi Shimizu, Marin Ishikawa, Satoshi Abiko, Yoshihiko Shimoda, Ikko Tanaka, Sayoko Kinowaki, Masayoshi Ono, Keiko Yamamoto, Shoko Ono and Naoya Sakamoto
Funding Agency and Grant Number
Corresponding Author	Yuichi Shimizu, MD, PhD, Associate Professor, Division of Endoscopy, Hokkaido University Hospital, Nishi-5, Kita-14, Kita-ku, Sapporo 060-8648, Japan, Sapporo 060-8648, Japan. yshimizu@med.hokudai.ac.jp
Key Words	Human papillomavirus; Esophageal squamous cell carcinoma; Early esophageal cancer; Alcohol dehydrogenase-1B; Aldehyde dehydrogenase-2; Endoscopic resection
Core Tip	We examined esophageal squamous cell carcinoma (ESCC) tissues obtained by endoscopic mucosal resection or endoscopic submucosal dissection for human papillomavirus (HPV) infection. Genotyping of alcohol dehydrogenase-1B (ADH1B)/ aldehyde dehydrogenase-2 (ALDH2) by using saliva sampling was performed. As a result, significant differences were not found between HPV infection and ADH1B/ALDH2. However, results of investigations including investigation of genetic polymorphisms in alcohol metabolism were shown for the first time, and there has so far been study on only early ESCC. We therefore consider the results of our study to be important.
Citation	Inoue M, Shimizu Y, Ishikawa M, Abiko S, Shimoda Y, Tanaka I, Kinowaki S, Ono M, Yamamoto K, Ono S, Sakamoto N. Relationships of early esophageal cancer with human papillomavirus and alcohol metabolism. World J Clin Cases 2020; 26(39): 6047-6056

Received	2020-07-01 09:46
Peer-Review Started	2020-07-01 09:47
To Make the First Decision
Return for Revision	2020-07-28 20:41
Revised	2020-08-13 15:08
Second Decision	2020-09-24 12:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-09-25 05:29
Articles in Press	2020-09-25 05:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-10-19 00:59

ISSN	1007-9327 (print) and 2219-2840 (online)
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