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9/25/2020 6:58:06 PM | Browse: 186 | Download: 289
Publication Name World Journal of Stem Cells
Manuscript ID 58085
Country/Territory Spain
Category Cell Biology
Manuscript Type Basic Study
Article Title Glutathione metabolism is essential for self-renewal and chemoresistance of pancreatic cancer stem cells
Manuscript Source Invited Manuscript
All Author List Petra Jagust, Sonia Alcalá, Bruno Sainz Jr, Christopher Heeschen and Patricia Sancho
Funding Agency and Grant Number
Funding Agency Grant Number
Fondo Investigaciones Sanitarias PI17/00082
Instituto de Salud Carlos III and European Funds (FSE: “el FSE invierte en tu futuro” and FEDER: “una manera de hacer Europa”) Miguel Servet Fellowship CP16/00121
European Community's Seventh Framework Programme 602783
ERC Advanced Investigator Program Pa-CSC 233460
Corresponding Author Patricia Sancho, PhD, Senior Scientist, Hospital Universitario Miguel Servet, IIS Aragon, Isabel la Católica 1-3, Zaragoza 50009, Spain. psancho@iisaragon.es
Key Words Pancreatic cancer; Cancer stem cells; Glutathione; Self-renewal; Chemoresistance; Redox
Core Tip Several glutathione metabolism genes are upregulated in pancreatic cancer stem cells (CSCs), and their expression correlates with a stemness signature and predicts survival in clinical samples. Increased glutathione concentration in CSCs promotes viability, cell cycle progression and pluripotency gene expression. Inhibition of glutathione synthesis or recycling impairs CSC functionalities such as self-renewal and chemoresistance. Our data demonstrate a targetable metabolic vulnerability of this aggressive subpopulation of cancer cells.
Citation Jagust P, Alcalá S, Sainz Jr B, Heeschen C, Sancho P. Glutathione metabolism is essential for self-renewal and chemoresistance of pancreatic cancer stem cells. World J Stem Cells 2020; 12(11): 1410-1428
Received
2020-07-10 09:24
Peer-Review Started
2020-07-10 09:25
To Make the First Decision
Return for Revision
2020-08-09 14:56
Revised
2020-08-19 10:27
Second Decision
2020-09-25 10:07
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-09-25 18:58
Articles in Press
2020-09-25 18:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-10-10 06:57
Typeset the Manuscript
2020-11-19 07:49
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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