Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	59071
Country	Slovenia

Category	Oncology
Manuscript Type	Clinical and Translational Research
Article Title	Total neoadjuvant therapy vs standard therapy of locally advanced rectal cancer with high-risk factors for failure
Manuscript Source	Unsolicited Manuscript
All Author List	Mojca Tuta, Nina Boc, Erik Brecelj, Monika Peternel and Vaneja Velenik
Funding Agency and Grant Number
Corresponding Author	Vaneja Velenik, MD, PhD, Associate Professor, Division of Radiotherapy, Institute of Oncology, Zaloška cesta 2, Ljubljana 1000, Slovenia. vvelenik@onko-i.si
Key Words	Locally advanced rectal cancer; Total neoadjuvant therapy; Pathological complete response; Neoadjuvant rectal cancer score
Core Tip	Our data suggest that treatment of locally advanced rectal cancer (LARC) with high-risk factors for failure using total neoadjuvant therapy (TNT) is more effective than standard therapy, achieving a higher rate of pathological complete response, more favourable survival prognosis, higher proportion of T-and N-downstaging, shorter time to temporary stoma closure, better compliance, and lower toxicity grade 3-5 during systemic chemotherapy. The outcomes of TNT in patients with the most aggressive form of LARC are completely comparable to TNT in all patients with LARC.
Citation	Tuta M, Boc N, Brecelj E, Peternel M, Velenik V. Total neoadjuvant therapy vs standard therapy of locally advanced rectal cancer with high-risk factors for failure. World J Gastrointest Oncol 2021; 13(2): 119-130

Received	2020-09-27 12:21
Peer-Review Started	2020-09-27 12:21
To Make the First Decision
Return for Revision	2020-12-12 18:36
Revised	2020-12-22 11:35
Second Decision	2021-01-05 02:50
Accepted by Journal Editor-in-Chief	2021-01-06 04:01
Accepted by Company Editor-in-Chief	2021-01-07 20:20
Articles in Press	2021-01-07 20:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-01-28 07:10

ISSN	1948-5204 (online)
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