Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	59973
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Retrospective research of neoadjuvant therapy on tumor-downstaging, post-operative complications and prognosis in locally advanced rectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Wen-Chang Li, Jing-Kun Zhao, Wen-Qing Feng, Yi-Ming Miao, Zi-Feng Xu, Zhuo-Qing Xu, Han Gao, Jing Sun, Min-Hua Zheng, Ya-Ping Zong and Ai-Guo Lu
Funding Agency and Grant Number	Funding Agency Grant Number National Science Foundation of China 81871933 National Science Foundation of China for Youth 81802326
Corresponding Author	Ai-Guo Lu, MD, PhD, Chief Doctor, Professor, Department of General Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No. 197 Ruijin 2nd Road, Shanghai 200025, China. luaiguo1965@163.com
Key Words	Locally advanced rectal cancer; Neoadjuvant therapy; Tumor downstaging; Postoperative complications; Prognosis
Core Tip	Neoadjuvant therapy can cause tumor downstaging preoperatively or even complete remission of the primary tumor. Radiochemotherapy had better T downstaging as well as promising overall survival without major complications. This may help clinicians realize the indispensability of preoperative radiation.
Citation	Li WC, Zhao JK, Feng WQ, Miao YM, Xu ZF, Xu ZQ, Gao H, Sun J, Zheng MH, Zong YP, Lu AG. Retrospective research of neoadjuvant therapy on tumor-downstaging, post-operative complications and prognosis in locally advanced rectal cancer. World J Gastrointest Surg 2021; 13(3): 267-278

Received	2020-10-11 13:08
Peer-Review Started	2020-10-09 15:22
To Make the First Decision
Return for Revision	2020-12-08 07:49
Revised	2020-12-13 09:56
Second Decision	2021-01-08 04:11
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-01-15 19:27
Articles in Press	2021-01-15 19:27
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-01-22 23:07
Typeset the Manuscript	2021-02-14 02:31

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com