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Publication Name World Journal of Gastroenterology
Manuscript ID 60026
Country/Territory Taiwan
Category Gastroenterology & Hepatology
Manuscript Type Case Report
Article Title Vedolizumab in Crohn’s disease with rectal fistulas and presacral abscess: A case report
Manuscript Source Unsolicited Manuscript
All Author List Heng Yeh, Chia-Jung Kuo, Ren-Chin Wu, Chien-Ming Chen, Wen-Sy Tsai, Ming-Yao Su, Cheng-Tang Chiu and Puo-Hsien Le
Funding Agency and Grant Number
Corresponding Author Puo-Hsien Le, MD, Assistant Professor, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou Branch, No. 5 Fuxing Street, Guishan District, Taoyuan 333, Taiwan. puohsien@gmail.com
Key Words Vedolizumab; Crohn's disease; Rectoprostatic fistula; Rectal pre-sacral fistula; Pre-sacral abscess; Case report
Core Tip Fistulas and intraabdominal fistulas are common complications of Crohn’s disease (CD) and tumor necrosis factor antagonists combined with percutaneous drainage or surgical intervention is the optimal treatment for fistulizing CD with intraabdominal abscess. However, no previous study has reported the efficacy of vedolizumab in this complicated situation. This 47-year-old male presented with CD with complex fistulas and pre-sacral abscess. He received vedolizumab with transverse colostomy and the follow-up sigmoidoscopy 6 mo later showed mucosal healing without any visible fistula tracts. We think early vedolizumab treatment with stool diversion are effective and safe in treating CD with complex fistulas and abscess formation.
Citation Yeh H, Kuo CJ, Wu RC, Chen CM, Tsai WS, Su MY, Chiu CT, Le PH. Vedolizumab in Crohn’s disease with rectal fistulas and presacral abscess: A case report. World J Gastroenterol 2021; 27(5): 442-448
Received
2020-10-12 12:29
Peer-Review Started
2020-10-12 12:30
To Make the First Decision
Return for Revision
2020-11-23 06:10
Revised
2020-12-08 09:35
Second Decision
2021-01-06 12:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-01-06 18:32
Articles in Press
2021-01-06 18:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-01-26 11:41
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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