Publication Name	World Journal of Gastroenterology
Manuscript ID	61576
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Validation of serum tumor biomarkers in predicting advanced cystic mucinous neoplasm of the pancreas
Manuscript Source	Unsolicited Manuscript
All Author List	Li-Qi Sun, Li-Si Peng, Jie-Fang Guo, Fei Jiang, Fang Cui, Hao-Jie Huang and Zhen-Dong Jin
Funding Agency and Grant Number	Funding Agency Grant Number Shanghai Association for Science and Technology 19411951602 National Natural Science Foundation of China 81770642
Corresponding Author	Zhen-Dong Jin, MD, PhD, Director, Professor, Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Changhai Road No. 168 Yangpu District, Shanghai 200433, China. zhendongjin@163.com
Key Words	Serum tumor markers; Diagnosis; Advanced cystic mucinous neoplasms; Mucinous cystic neoplasms; Intraductal papillary mucinous neoplasms
Core Tip	The value of serum tumor markers (STMs) in predicting advanced cystic mucinous neoplasms (A-cMNs) has not been well studied except for carbohydrate antigen (CA) 19-9. Our study illustrates for the first time the potential value of multiple STMs in the diagnosis of A-cMNs. CA19-9 was the most accurate STM in predicting A-cMNs with a moderate ability. CEA, CA125 and CA724 showed a low ability to predict A-cMNs. CA125 may be specific to the diagnosis of advanced mucinous cystic neoplasms. CA242 was not identified as useful in predicting A-cMNs in our study. The combination of STMs could improve sensitivity in predicting A-cMNs.
Citation	Sun LQ, Peng LS, Guo JF, Jiang F, Cui F, Huang HJ, Jin ZD. Validation of serum tumor biomarkers in predicting advanced cystic mucinous neoplasm of the pancreas. World J Gastroenterol 2021; 27(6): 501-512

Received	2020-12-12 11:51
Peer-Review Started	2020-12-12 11:53
To Make the First Decision
Return for Revision	2020-12-17 19:56
Revised	2020-12-30 14:40
Second Decision	2021-01-12 12:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-01-12 18:12
Articles in Press	2021-01-12 18:12
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-01-24 08:31
Typeset the Manuscript	2021-02-03 02:24

ISSN	1007-9327 (print) and 2219-2840 (online)
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