Publication Name	World Journal of Psychiatry
Manuscript ID	61711
Country	Denmark

Category	Neurosciences
Manuscript Type	Review
Article Title	Prenatal nicotine alters development of the laterodorsal tegmentum: Possible role for attention-deficit/hyperactivity disorder and drug dependence
Manuscript Source	Invited Manuscript
All Author List	Filip S Polli and Kristi A Kohlmeier
Funding Agency and Grant Number
Corresponding Author	Kristi A Kohlmeier, PhD, Associate Professor, Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, Copenhagen 2100, Denmark. kak1@sund.ku.dk
Key Words	Prenatal nicotine exposure; Pregnancy outcome; Addiction risk; Laterodorsal tegmentum; Arousal; Attention
Core Tip	Offspring of women who used nicotine-containing products while pregnant exhibit risk factors for later-life development of cognitive deficits, including attention deficit/hyperactivity disorder and drug dependence. This suggests that circuits that play a role in cognition are being altered by nicotine. The laterodorsal tegmental nucleus of the pons plays a role in attention, motivation, and other cognitive-related processes, and nicotine during gestation has been shown in animal studies to alter functioning of this nucleus. In this review, we discuss the human and animal literature that indicate that alterations in functioning of the laterodorsal tegmental nucleus could arise following prenatal nicotine exposure, and that these alterations could play a role in the negative risks associated with early-life nicotine exposure.
Citation	Polli FS, Kohlmeier KA. P Prenatal nicotine alters development of the laterodorsal tegmentum: Possible role for attention-deficit/hyperactivity disorder and drug dependence. World J Psychiatr 2022; 12(2): 212-235

Received	2021-02-01 14:18
Peer-Review Started	2021-02-01 14:20
To Make the First Decision
Return for Revision	2021-07-28 21:58
Revised	2021-08-07 08:40
Second Decision	2022-01-13 05:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-01-14 06:32
Articles in Press	2022-01-14 06:32
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-12-19 01:10
Typeset the Manuscript	2022-02-09 08:05

ISSN	2220-3206 (online)
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