Publication Name	World Journal of Gastroenterology
Manuscript ID	61980
Country	China

Category	Oncology
Manuscript Type	Clinical and Translational Research
Article Title	Survival-associated alternative splicing events interact with immune microenvironment in stomach adenocarcinoma
Manuscript Source	Invited Manuscript
All Author List	Zai-Sheng Ye, Miao Zheng, Qin-Ying Liu, Yi Zeng, Sheng-Hong Wei, Yi Wang, Zhi-Tao Lin, Chen Shu, Qiu-Hong Zheng and Lu-Chuan Chen
Funding Agency and Grant Number	Funding Agency Grant Number National Clinical Key Specialty Construction Program of China and Grants from the National Science Foundation Project of the Fujian Science and Technology Department 2017J01264 Foundation for Fujian Provincial Health Technology Project 2019-ZQN-16 National Clinical Key Specialty Construction Program of China and Grants from the National Science Foundation Project of the Fujian Science and Technology Department 2018Y0015 Foundation for Fujian Provincial Health Technology Project 2019-CXB-9 Foundation for Fujian Provincial Health Technology Project 2019006 Startup Fund for Scientific Research, Fujian Medical University 2017Q1219 Startup Fund for Scientific Research, Fujian Medical University 2017Q1220
Corresponding Author	Lu-Chuan Chen, BM BCh, MD, Chief Doctor, Director, Surgical Oncologist, Teacher, Department of Gastrointestinal Surgical Oncology, Fujian Cancer Hospital & Fujian Medical University Cancer Hospital, Fuma Road420@, Jin an District, Fuzhou 350014, Fujian , China. luchuanchen@fjzlhospital.com
Key Words	Stomach adenocarcinoma; Alternative splicing; Tumor microenvironment; Immune-related genes and pathways
Core Tip	In this study, we performed a systematic analysis of prognostic splicing events in stomach adenocarcinoma (STAD), constructed an elevated Alternative splicing (AS)-signature prognostic model, and explored the association between AS and cancer immunity. The final overall survival-related AS events, differentially expressed immune-related genes, and the enriched pathways may play an important role in tumorigenesis in STAD; they deserve further study in clinical applications as diagnostic biomarkers and therapeutic targets.
Citation	Ye ZS, Zheng M, Liu QY, Zeng Y, Wei SH, Wang Y, Lin ZT, Shu C, Zheng QH, Chen LC. Survival-associated alternative splicing events interact with immune microenvironment in stomach adenocarcinoma. World J Gastroenterol 2021; 27(21): 2871-2894

Received	2020-12-28 13:49
Peer-Review Started	2020-12-25 00:26
To Make the First Decision
Return for Revision	2021-01-17 00:37
Revised	2021-01-23 15:36
Second Decision	2021-04-08 06:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-04-09 17:58
Articles in Press	2021-04-09 17:58
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-05-07 13:40
Typeset the Manuscript	2021-05-25 03:17

ISSN	1007-9327 (print) and 2219-2840 (online)
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