Publication Name	World Journal of Gastroenterology
Manuscript ID	62330
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Validation of conventional non-invasive fibrosis scoring systems in patients with metabolic associated fatty liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Yin-Lian Wu, Rahul Kumar, Ming-Fang Wang, Medha Singh, Jiao-Feng Huang, Yue-Yong Zhu and Su Lin
Funding Agency and Grant Number	Funding Agency Grant Number Chinese National 13th Five-Year Plan's Science and Technology Projects 2017ZX10202201
Corresponding Author	Su Lin, MD, PhD, Associate Chief Physician, Professor, Department of Hepatology, Hepatology Research Institute, The First Affiliated Hospital, Fujian Medical University, No. 20 Chazhong Road, Taijiang District, Fuzhou 350005, Fujian Province, China. sumer5129@fjmu.edu.cn
Key Words	Metabolic associated fatty liver disease; Non-invasive fibrosis scores; Fibrosis-4 index; Non-alcoholic fatty liver disease fibrosis score; Aspartate aminotransferase to platelet ratio index; BARD
Core Tip	Metabolic associated fatty liver disease (MAFLD) is a new concept proposed in 2020 to re-define fatty liver disease. The utility of non-invasive fibrosis scores as well as their optimal thresholds for MAFLD remains unknown. We validated the conventional non-invasive scores including aspartate aminotransferase to platelet ratio index, fibrosis-4 index, diabetes score (BARD), and non-alcoholic fatty liver disease fibrosis score in patients with MAFLD. The results indicate that the conventional scores may lead to a high rate of misdiagnosis in MAFLD. Novel scoring system for fibrosis is urgently needed.
Citation	Wu YL, Kumar R, Wang MF, Singh M, Huang JF, Zhu YY, Lin S. Validation of conventional non-invasive fibrosis scoring systems in patients with metabolic associated fatty liver disease. World J Gastroenterol 2021; 27(34): 5753-5763

Received	2021-01-06 13:44
Peer-Review Started	2021-01-06 13:45
To Make the First Decision
Return for Revision	2021-05-05 22:18
Revised	2021-05-15 09:29
Second Decision	2021-07-29 02:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-07-29 08:06
Articles in Press	2021-07-29 08:06
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-08-17 21:14
Typeset the Manuscript	2021-09-02 03:46

ISSN	1007-9327 (print) and 2219-2840 (online)
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