Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	62553
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Diagnosis of anorectal tuberculosis by polymerase chain reaction, GeneXpert and histopathology in 1336 samples in 776 anal fistula patients
Manuscript Source	Invited Manuscript
All Author List	Pankaj Garg, Ankita Goyal, Vipul D Yagnik, Sushil Dawka and Geetha R Menon
Funding Agency and Grant Number
Corresponding Author	Pankaj Garg, MBBS, MS, Surgeon, Department of Colorectal Surgery, Indus International Hospital, Near Dera Bassi, Mohali 140507, Punjab, India. drgargpankaj@yahoo.com
Key Words	Anal fistula; Fistula-in-ano; Tuberculosis, Histopathology, Polymerase chain-reaction, GeneXpert
Core Tip	This is the largest study of anorectal tuberculosis (TB) to be reported. A total of 1336 tissue and pus samples were tested in 776 patients over 6 years. Polymerase chain-reaction, GeneXpert and histopathology were utilized to detect TB in these samples. Polymerase chain-reaction was more sensitive than histopathology and GeneXpert to detect TB in anal fistulas. This is the first study in which these three methods have been compared in the same cohort. Pus was more sensitive than tissue samples to detect TB. TB fistula had a significantly higher proportion of complex fistulas but timely diagnosis and treatment led to a high success rate in these fistulas.
Citation	Garg P, Goyal A, Yagnik V, Dawka S, Menon GR. Diagnosis of anorectal tuberculosis by polymerase chain reaction, GeneXpert and histopathology in 1336 samples in 776 anal fistula patients. World J Gastrointest Surg 2021; 13(4): 355-365

Received	2021-01-12 08:17
Peer-Review Started	2021-01-12 08:18
To Make the First Decision
Return for Revision	2021-02-11 01:01
Revised	2021-02-11 12:19
Second Decision	2021-04-06 08:12
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-04-14 14:29
Articles in Press	2021-04-14 14:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-04-20 01:37

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com