Publication Name	World Journal of Clinical Cases
Manuscript ID	62796
Country	China

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Histological transformation of non-small cell lung cancer: Clinical analysis of nine cases
Manuscript Source	Unsolicited Manuscript
All Author List	Cai-Bao Jin and Ling Yang
Funding Agency and Grant Number
Corresponding Author	Ling Yang, MD, Chief Doctor, Department of Thoracic Oncology, Hubei Cancer Hospital, No. 116 Zhuodaoquan South Road, Wuhan 430000, Hubei Province, China. 348711624@qq.com
Key Words	Histological transformation; Epidermal growth factor receptor tyrosine kinase inhibitors; Non-small cell lung cancer; Tumor re-biopsy; Epidermal growth factor receptor mutation
Core Tip	We retrospectively diagnosed 9 cases of non-small cell lung cancer (SCLC) transforming to SCLC, large-cell neuroendocrine carcinoma or squamous cell carcinoma on re-biopsy after epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). Tumor re-biopsy should be performed routinely when EGFR-TKI therapy fails in lung cancer patients to avoid ignoring histological transformation and to select a subsequent therapeutic strategy. The plasma pro-gastrin-releasing peptide and NSE levels could be valuable and significant biomarkers to predict histological transformation. The transformed tumor retained the original EGFR mutation, which indicates that histological transformation represents an evolution from the initial tumor.
Citation	Jin CB, Yang L. Histological transformation of non-small cell lung cancer: Clinical analysis of nine cases. World J Clin Cases 2021; 9(18): 4617-4626

Received	2021-01-26 14:56
Peer-Review Started	2021-01-26 14:58
To Make the First Decision
Return for Revision	2021-02-25 04:02
Revised	2021-03-11 05:46
Second Decision	2021-04-12 12:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-04-12 17:26
Articles in Press	2021-04-12 17:26
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-04-16 01:41
Typeset the Manuscript	2021-05-31 11:42

ISSN	2307-8960 (online)
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