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4/13/2021 2:35:48 PM | Browse: 146 | Download: 221
Publication Name World Journal of Gastroenterology
Manuscript ID 62850
Country/Territory Greece
Category Infectious Diseases
Manuscript Type Review
Article Title Towards a new era of hepatitis B virus therapeutics: The pursuit of functional cure
Manuscript Source Invited Manuscript
All Author List Efthymios P Tsounis, Evanthia Tourkochristou, Athanasia Mouzaki and Christos Triantos
Funding Agency and Grant Number
Corresponding Author Christos Triantos, FAASLD, MD, PhD, Assistant Professor, Division of Gastroenterology, Department of Internal Medicine, Medical School, University of Patras, D. Stamatopoulou 4, Rio, Patras 26504, Greece. chtriantos@hotmail.com
Key Words Chronic hepatitis B; Functional cure; Direct-acting antivirals; Gene silencing; Immunotherapy; Therapeutic vaccination
Core Tip Despite preventive vaccination and effective anti-viral drugs, approximately 300 million people worldwide are at risk of liver-related morbidity and mortality from hepatitis B virus (HBV) infection. In the search for more effective strategies, research has focused on two broad categories of therapeutic interventions. First, direct-acting antivirals that interrupt various stages of the HBV life cycle are yielding promising results in clinical trials and suppress HBV antigen load. Second, the need to address depleted immune responses and revive the tolerogenic liver microenvironment has brought immunotherapies to the forefront. It is likely that HBV elimination will occur through an upcoming treatment that combines agents from both classes.
Citation Tsounis EP, Tourkochristou E, Mouzaki A, Triantos C. Towards a new era of hepatitis B virus therapeutics: the pursuit of functional cure. World J Gastroenterol 2021; 27(21): 2727-2757
Received
2021-01-20 10:02
Peer-Review Started
2021-01-20 10:04
To Make the First Decision
Return for Revision
2021-02-09 19:27
Revised
2021-02-23 11:41
Second Decision
2021-04-08 07:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-04-13 14:35
Articles in Press
2021-04-13 14:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-05-06 22:28
Typeset the Manuscript
2021-05-19 00:14
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
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