Publication Name	World Journal of Gastroenterology
Manuscript ID	62969
Country	China

Category	Microbiology
Manuscript Type	Observational Study
Article Title	Gut microbiota dysbiosis in Chinese children with type 1 diabetes mellitus: An observational study
Manuscript Source	Invited Manuscript
All Author List	Xia Liu, Yi-Wen Cheng, Li Shao, Shu-Hong Sun, Jian Wu, Qing-Hai Song, Hong-Sheng Zou and Zong-Xin Ling
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 31700800 National Natural Science Foundation of China 81771724 National S&T Major Project of China 2018YFC2000500 National Natural Science Foundation of China 81790631
Corresponding Author	Zong-Xin Ling, PhD, Professor, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang Univeristy, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. lingzongxin_lzx@163.com
Key Words	Dysbiosis; Fasting blood glucose; Sequencing; Metabolism; Type 1 diabetes mellitus
Core Tip	Alterations in the gut microbiota play vital roles in the development of autoimmune diseases such as type 1 diabetes mellitus (T1DM). Our present study explores the overall structure and composition of the fecal microbiota in Chinese children with T1DM and on its association with fasting blood glucose (FBG). We found that the bacterial diversity increased significantly in children with T1DM and that several key functional taxa were correlated with FBG. These key functional bacteria could be used as noninvasive diagnostic biomarkers to discriminate T1DM patients from healthy controls. This comprehensive investigation of the T1DM-associated fecal microbiota provides novel insights into the pathogenesis of T1DM.
Citation	Liu X, Cheng YW, Shao L, Sun SH, Wu J, Song QH, Zou HS, Ling ZX. Gut microbiota dysbiosis in Chinese children with type 1 diabetes mellitus: An observational study. World J Gastroenterol 2021; 27(19): 2394-2414

Received	2021-01-23 02:55
Peer-Review Started	2021-01-23 03:00
To Make the First Decision
Return for Revision	2021-02-10 06:51
Revised	2021-02-17 10:13
Second Decision	2021-04-12 07:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-04-14 17:09
Articles in Press	2021-04-14 17:09
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-04-17 14:12
Typeset the Manuscript	2021-05-11 01:18

ISSN	1007-9327 (print) and 2219-2840 (online)
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