Publication Name	World Journal of Gastroenterology
Manuscript ID	63117
Country	Chile

Category	Research & Experimental Medicine
Manuscript Type	Review
Article Title	Receptor for advanced glycation end-products axis and COVID-19 in inflammatory bowel diseases: A dangerous liaison?
Manuscript Source	Invited Manuscript
All Author List	Armando Rojas, Iván Schneider, Cristian Lindner, Ileana Gonzàlez and Miguel Angel Morales
Funding Agency and Grant Number
Corresponding Author	Armando Rojas, PhD, Full Professor, Biomedical Research Labs, Medicine Faculty, Catholic University of Maule, 3605 San Miguel Ave, Talca 3634000, Chile. arojasr@ucm.cl
Key Words	COVID-19; Inflammatory bowel diseases; Advanced glycation; Angiotensin-converting enzyme 2; Alarmins; Receptor for advanced glycation end-products; Receptor for advanced glycation end-products axis; Inflammation
Core Tip	Data raised during the pandemic suggest that inflammatory bowel diseases (IBD) do not have an increased risk of contracting severe acute respiratory syndrome coronavirus 2 infection or develop a more severe course of infection. These findings are in some way unexpected considering that IBD is a chronic inflammatory state of the gastrointestinal tract. We herein discuss how the receptor for advanced glycation end-products (RAGE) axis activation as well as the cross-talk with the renin-angiotensin system are dampened by the high expression of soluble forms of both RAGE and angiotensin-converting enzyme 2.
Citation	Rojas A, Schneider I, Lindner C, Gonzàlez I, Morales MA. Receptor for advanced glycation end-products axis and COVID-19 in inflammatory bowel diseases: A dangerous liaison? World J Gastroenterol 2021; 27(19): 2270-2280

Received	2021-01-24 20:49
Peer-Review Started	2021-01-24 20:53
To Make the First Decision
Return for Revision	2021-02-22 06:09
Revised	2021-02-22 16:24
Second Decision	2021-04-08 12:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-04-14 04:17
Articles in Press	2021-04-14 04:17
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-04-21 03:40
Typeset the Manuscript	2021-05-12 00:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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