Publication Name	World Journal of Gastroenterology
Manuscript ID	63120
Country	Canada

Category	Oncology
Manuscript Type	Minireviews
Article Title	<Iitalic>BRCA</Italic> mutated pancreatic cancer: A change is coming
Manuscript Source	Invited Manuscript
All Author List	Michael N Rosen, Rachel A Goodwin and Michael M Vickers
Funding Agency and Grant Number
Corresponding Author	Michael M Vickers, FRCPC, MD, Assistant Professor, Doctor, The Ottawa Hospital Cancer Center, The University of Ottawa, 501 Smyth Road, Ottawa K1H 8L6, Ontario, Canada. mvickers@toh.ca
Key Words	Pancreatic cancer; Systemic therapy; Platinum chemotherapy; Breast cancer susceptibility gene; Deoxyribonucleic acid repair; Poly (ADP-ribose) polymerase inhibitors
Core Tip	Recent advances in the field of breast cancer susceptibility gene (BRCA)-mutated pancreatic cancer suggest that these patients benefit from platinum-based chemotherapy regimens. In light of new findings from the Pancreas Cancer Olaparib Ongoing trial, patients with germline BRCA mutations may benefit from maintenance treatment with olaparib, a Poly (ADP-ribose) polymerase inhibitors following response to platinum-based chemotherapy. Based on these important findings, all pancreatic cancer patients should be offered early access to genetic screening in order to identify patients who will benefit from these therapies.
Citation	Rosen MN, Goodwin RA, Vickers MM. Breast cancer susceptibility gene mutated pancreatic cancer: A change is coming. World J Gastroenterol 2021; 27(17): 1943-1958

Received	2021-01-25 00:19
Peer-Review Started	2021-01-25 00:23
To Make the First Decision
Return for Revision	2021-02-27 23:05
Revised	2021-03-04 19:25
Second Decision	2021-04-12 12:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-04-13 14:15
Articles in Press	2021-04-13 14:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-04-22 06:58

ISSN	1007-9327 (print) and 2219-2840 (online)
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