Publication Name	World Journal of Stem Cells
Manuscript ID	63323
Country	Italy

Category	Oncology
Manuscript Type	Review
Article Title	Mechanisms involved in selecting and maintaining neuroblastoma cancer stem cell populations, and perspectives for therapeutic targeting
Manuscript Source	Invited Manuscript
All Author List	Antonietta Rosella Farina, Lucia Annamaria Cappabianca, Veronica Zelli, Michela Sebastiano and Andrew Reay Mackay
Funding Agency and Grant Number
Corresponding Author	Andrew Reay Mackay, PhD, Associate Professor, Department of Applied Clinical and Biotechnological Sciences, University of L'Aquila, Via Vetoio, Coppito 2, L'Aquila 67100, AQ, Italy. andrewreay.mackay@univaq.it
Key Words	Neural crest; Neuroblastoma; Cancer stem cells; Polyploid giant cancer cells molecular mechanisms; Therapeutic targeting; Tumor microenvironment
Core Tip	Cancer stem cells promote tumor-heterogeneity, post-therapeutic relapse and metastatic progression in neuroblastomas, by way of their drug-resistant, self-renewing and reversibly plastic phenotypes, and are, therefore, critical targets to eliminate if improvements in therapeutic outcomes are to be realized. Despite progress in understanding molecular mechanisms that underpin neuroblastomas (NB) cancer stem cell (CSC) selection, promotion and maintenance, efficacious CSC targeting remains difficult. Here we review molecular mechanisms considered to regulate NB CSCs, married with therapeutic strategies and future prospects for their eradication, highlighting the need for better understanding and targeting of polyploid giant cancer cell states, future prospects for CAR cell immunotherapies, the need to identify additional functional cell surface NB CSC-specific targets and to develop better models for NB CSC experimental therapeutics.
Citation	Farina AR, Cappabianca LA, Zelli V, Sebastiano M, Mackay AR. Mechanisms involved in selecting and maintaining neuroblastoma cancer stem cell populations, and perspectives for therapeutic targeting. World J Stem Cells 2021; 13(7): 685-736

Received	2021-01-27 10:40
Peer-Review Started	2021-01-27 10:43
To Make the First Decision
Return for Revision	2021-02-28 05:38
Revised	2021-03-09 16:45
Second Decision	2021-04-06 08:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-04-14 14:48
Articles in Press	2021-04-14 14:48
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-06-25 08:13
Typeset the Manuscript	2021-07-19 02:12

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
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