Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	64402
Country	Greece

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Role of autophagy in gastric carcinogenesis
Manuscript Source	Invited Manuscript
All Author List	Apostolis Papaefthymiou, Gregory Christodoulidis, Apostolos Koffas, Michael Doulberis, Stergios A Polyzos, Anastasios Manolakis, Spyros Potamianos, Andreas Kapsoritakis and Jannis Kountouras
Funding Agency and Grant Number
Corresponding Author	Apostolis Papaefthymiou, MD, PhD, N/A, Department of Gastroenterology, University Hospital of Larissa, Mezourlo, Larissa 41110, Thessaly, Greece. appapaef@hotmail.com
Key Words	Gastric cancer; Autophagy; Helicobacter pylori; Chemoresistance; Prognosis
Core Tip	Autophagy comprises a substantial normal cellular function, implicated in benign and malignant diseases. Its complex regulatory system can be affected at any stage by endogenous and environmental factors. Helicobacter pylori expresses and stimulates a wide range of autophagy modulators, thus promoting or inhibiting autophagy to yield a survival benefit and cause damage. Concerning gastric cancer, the dysregulated autophagic process facilitates tumor generation, progress and resistance to chemotherapy, through various mechanisms. The current review attempts to decrypt and simplify those mechanisms and the respective pathways, to explain their promising potential for the development of therapeutic agents and prognostic tools.
Citation	Papaefthymiou A, Christodoulidis G, Koffas A, Doulberis M, Polyzos SA, Manolakis A, Potamianos S, Kapsoritakis A, Kountouras J. Role of autophagy in gastric carcinogenesis. World J Gastrointest Oncol 2021; 13(10): 1244-1262

Received	2021-02-16 18:20
Peer-Review Started	2021-02-16 18:24
To Make the First Decision
Return for Revision	2021-03-29 21:19
Revised	2021-04-06 21:15
Second Decision	2021-08-02 02:49
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-08-02 07:42
Articles in Press	2021-08-02 07:42
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-08-15 23:59
Typeset the Manuscript	2021-09-30 08:32

ISSN	1948-5204 (online)
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