Publication Name	World Journal of Virology
Manuscript ID	65693
Country	China

Category	Biology
Manuscript Type	Minireviews
Article Title	Protein-protein interactions: Methods, databases and applications in virus-host study
Manuscript Source	Invited Manuscript
All Author List	Qurat ul Ain Farooq, Zeeshan Shaukat, Sara Aiman and Chun-Hua Li
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 31971180 National Natural Science Foundation of China 11474013
Corresponding Author	Chun-Hua Li, PhD, Professor, Faculty of Environmental and Life Sciences, Beijing University of Technology, No. 100 Pingleyuan, Chaoyang District, Beijing 100124, China. chunhuali@bjut.edu.cn
Key Words	Protein-protein interactions; Experimental and computational methods; Protein-protein interaction networks; Protein-protein interaction databases; Disease pathways; Protein-protein interaction applications
Core Tip	A comprehensive review on protein-protein interactions (PPIs), including the experimental and computational methods of finding PPIs, the databases dedicated to virus-host PPIs and the associated applications in the studies of some lethal viruses with their hosts. PPIs can be mapped into networks and innumerable novel insights into the functional organization of proteomes can be gained by analyzing the networks. Many researches have used network biology to construct PPI networks of lethal pathogens with their host Homo sapiens to dig deep down into the molecular constitution of the disease pathways, and have successfully found multiple potential drug targets against the viruses.
Citation	Farooq QUA, Shaukat Z, Aiman S, Li CH. Protein-protein interactions: Methods, databases and applications in virus-host study. World J Virol 2021; 10(6): 288-300

Received	2021-03-15 09:14
Peer-Review Started	2021-03-15 09:14
To Make the First Decision
Return for Revision	2021-04-06 16:56
Revised	2021-04-19 12:30
Second Decision	2021-07-30 03:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-07-30 06:37
Articles in Press	2021-07-30 06:37
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-08-09 13:10
Typeset the Manuscript	2021-11-16 03:04

ISSN	2220-3249 (online)
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