Publication Name	World Journal of Hepatology
Manuscript ID	65720
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Heterogeneity of non-alcoholic fatty liver disease: Implications for clinical practice and research activity
Manuscript Source	Invited Manuscript
All Author List	Partha Pal, Rajan Palui and Sayantan Ray
Funding Agency and Grant Number
Corresponding Author	Sayantan Ray, MBBS, MD, N/A, Department of Endocrinology, Jagannath Gupta Institute of Medical Sciences and Hospital, KP Mondal Road, Budge, Kolkata 700137, West Bengal, India. sayantan.ray30@gmail.com
Key Words	Non-alcoholic fatty liver disease; Metabolic-associated fatty liver disease; Heterogeneity; Phenotypes; nomenclature; Clinical trial; Effective therapies
Core Tip	It is being increasingly recognized that non-alcoholic fatty liver disease (NAFLD) is a heterogenous condition with wide variability in clinical presentation and natural history. This heterogeneity is driven by genetic predisposition, metabolic factors, gut microbiota, diet and demographic factors. The suboptimal response to current pharmacotherapy in NAFLD highlights the failure to recognize this heterogeneity. Experts believe that updating NAFLD nomenclature is the first step towards this. Identification of disease subtypes can help development of preclinical model evaluating novel targets. This would in turn help clinical trial design by comparing and pooling results and thus improve disease outcomes.
Citation	Pal P, Palui R, Ray S. Heterogeneity of nonalcoholic fatty liver disease: Implications for clinical practice and research activity. World J Hepatol 2021; 13(11): 1584-1610

Received	2021-03-14 08:22
Peer-Review Started	2021-03-14 08:39
To Make the First Decision
Return for Revision	2021-07-18 05:07
Revised	2021-07-29 12:07
Second Decision	2021-10-12 08:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-10-14 03:01
Articles in Press	2021-10-14 03:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-11-19 00:48

ISSN	1948-5182 (online)
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