Publication Name	World Journal of Gastroenterology
Manuscript ID	66080
Country	Norway

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Gut bless you: The microbiota-gut-brain axis in irritable bowel syndrome
Manuscript Source	Invited Manuscript
All Author List	Eline Margrete Randulff Hillestad, Aina van der Meeren, Bharat Halandur Nagaraja, Ben René Bjørsvik, Noman Haleem, Alfonso Benitez-Paez, Yolanda Sanz, Trygve Hausken, Gülen Arslan Lied, Arvid Lundervold and Birgitte Berentsen
Funding Agency and Grant Number	Funding Agency Grant Number The Spanish Ministry of Science and Innovation AGL2017-88801-P Norwegian Research Council FRIMEDBIO276010 Helse Vest's Research Funding HV912243 ERC H2020-MSCA-IF-2019 895219
Corresponding Author	Birgitte Berentsen, MSc, PhD, Associate Professor, National Center for Functional Gastrointestinal Disorders, Department of Medicine, Haukeland University Hospital, National Center for Functional Gastrointestinal Disorders, Department of Medicine, Haukeland University Hospital, Jonas Lies vei 65, 5021 Bergen, Norway , Bergen 5021, Norway. birgitte.berentsen1@helse-bergen.no
Key Words	Microbiota; Neurogastroenterology; Irritable bowel syndrome; Microbiota-gut-brain axis; Structural and functional magnetic resonance imaging; Machine learning; Big data analysis
Core Tip	Molecular biology, advanced neuroimaging and computer science is emerging to transform our understanding of the role of gut microbiota in irritable bowel syndrome (IBS). Herein, we provide an overview and discuss the role of gut microbiota in IBS, the clinical microbiota-altering interventions the low FODMAP diet and fecal microbiota transplantation, the role of brain-imaging and gut microbiota analyses, the importance of method selection, metadata, perspectives for improving microbiota role predictions, and big data analysis, in the seeking of understanding IBS pathology.
Citation	Hillestad EMR, van der Meeren A, Nagaraja BH, Bjørsvik BR, Haleem N, Benitez-Paez A, Sanz Y, Hausken T, Lied GA, Lundervold A, Berentsen B. Gut bless you: The microbiota-gut-brain axis in irritable bowel syndrome. World J Gastroenterol 2022; 28(4): 412-431

Received	2021-04-17 13:11
Peer-Review Started	2021-04-17 13:13
To Make the First Decision
Return for Revision	2021-06-03 18:00
Revised	2021-06-24 08:01
Second Decision	2022-01-12 03:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-01-12 21:44
Articles in Press	2022-01-12 21:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-01-13 09:18

ISSN	1007-9327 (print) and 2219-2840 (online)
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