Publication Name	World Journal of Clinical Oncology
Manuscript ID	66438
Country	Spain

Category	Oncology
Manuscript Type	Review
Article Title	New challenges in the combination of radiotherapy and immunotherapy in non-small cell lung cancer
Manuscript Source	Invited Manuscript
All Author List	Javier Luna, Juan Zafra, Mª Carmen Areses Manrique, Aurora Rodríguez, Amalia Sotoca, Jose Luis Fírvida, Rodolfo Chicas-Sett, Xabier Mielgo, Juan Carlos Trujillo Reyes and Felipe Couñago
Funding Agency and Grant Number
Corresponding Author	Javier Luna, PhD, Staff Physician, Department of Radiation Oncology, Oncohealth Institute, Fundación Jiménez Díaz, Reyes Catolicos Avenue No. 2, Madrid 28040, Spain. jluna@fjd.es
Key Words	Lung cancer; Radiotherapy; Immunotherapy; Main trials
Core Tip	Immunotherapy has revolutionised cancer treatment. Its association with radiotherapy has synergistic effects studied at a preclinical and clinical level, especially in metastatic patients. Currently, clinical research in this field is very prolific, and no doubt, as with the PACIFIC trial in non-small cell lung cancer (NSCLC), we will see further changes in the standard of care in the coming years. This review highlights the most important published work in NSCLC in the field of radio-immunotherapy, listing the clinical trials currently existing in each stage of NSCLC.
Citation	Luna J, Zafra J, Areses Manrique MC, Rodríguez A, Sotoca A, Fírvida JL, Chicas-Sett R, Mielgo X, Reyes JCT, Couñago F. New challenges in the combination of radiotherapy and immunotherapy in non-small cell lung cancer. World J Clin Oncol 2021; 12(11): 983-999

Received	2021-03-28 19:19
Peer-Review Started	2021-03-28 19:28
To Make the First Decision
Return for Revision	2021-06-25 10:42
Revised	2021-07-06 23:51
Second Decision	2021-10-11 08:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-10-14 03:05
Articles in Press	2021-10-14 03:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-11-17 06:02

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com