Publication Name	World Journal of Gastroenterology
Manuscript ID	67394
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Recombinant angiopoietin-like protein 4 attenuates intestinal barrier structure and function injury after ischemia/reperfusion
Manuscript Source	Unsolicited Manuscript
All Author List	Zi-Yi Wang, Jian-Yu Lin, Yang-Rong Feng, De-Shun Liu, Xu-Zi Zhao, Tong Li, Si-Yuan Li, Jing-Chao Sun, Shu-Feng Li, Wen-Yan Jia and Hui-Rong Jing
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81600446 Science and Technology of Traditional Chinese Medicine Foundation in Qingdao 2021-zyyz03 Science and technology development of Medicine and health Foundation in Shandong Province, China 202004010508
Corresponding Author	Hui-Rong Jing, MD, PhD, Associate Professor, Surgeon, Department of General Surgery, Qingdao Municipal Hospital, Qingdao University, No. 5 Donghai Middle Road, Southern District, Qingdao 266071, Shandong , China. jhrdlmu_edu@126.com
Key Words	Angiopoietin-like protein 4; Intestinal ischemia/reperfusion; COVID-19; Myosin light chain kinase; Intestinal barrier breakdown
Core Tip	To push the improvement of therapy on intestinal barrier dysfunction induced by ischemia/reperfusion (I/R) is still be challenging. Almost recently, studies indicated patients who suffered coronavirus disease-2019 associated with intestinal hypoperfusion. We investigated the effect of Recombinant human angiopoietin-like protein 4 (rhANGPTL4) on intestinal barrier structure and function deterioration using intestinal I/R models in rats as well as hypoxia/reoxygenation models in cells. Intestinal barrier indicators, associated with inflammatory and oxidative cascade, excessive activation of cellular autophagy and apoptosis were compared. Our results indicated rhANGPTL4 behaved as a promising therapeutic agent for intestinal I/R-induced intestine injury.
Citation	Wang ZY, Lin JY, Feng YR, Liu DS, Zhao XZ, Li T, Li SY, Sun JC, Li SF, Jia WY, Jing HR. Recombinant angiopoietin-like protein 4 attenuates intestinal barrier structure and function injury after ischemia/reperfusion. World J Gastroenterol 2021; 27(32): 5404-5423

Received	2021-04-24 06:59
Peer-Review Started	2021-04-24 07:03
To Make the First Decision
Return for Revision	2021-06-03 03:56
Revised	2021-06-17 06:04
Second Decision	2021-07-30 03:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-07-30 09:15
Articles in Press	2021-07-30 09:15
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-08-08 19:09
Typeset the Manuscript	2021-08-23 01:50

ISSN	1007-9327 (print) and 2219-2840 (online)
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