Publication Name	World Journal of Clinical Cases
Manuscript ID	67663
Country	Romania

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Did the severe acute respiratory syndrome-coronavirus 2 pandemic cause an endemic Clostridium difficile infection?
Manuscript Source	Invited Manuscript
All Author List	Camelia Cojocariu, Irina Girleanu, Anca Trifan, Andrei Olteanu, Cristina Maria Muzica, Laura Huiban, Stefan Chiriac, Ana Maria Singeap, Tudor Cuciureanu, Catalin Sfarti and Carol Stanciu
Funding Agency and Grant Number
Corresponding Author	Anca Trifan, FRCP, MD, Teacher, Department of Gastroenterology, “Grigore T. Popa” University of Medicine and Pharmacy, “St. Spiridon” University Hospital, Institute of Gastroenterology and Hepatology, Str. Universității no 16, Iasi 700115, Romania. ancatrifan@yahoo.com
Key Words	COVID-19 infection; Clostridium difficile infection; Risk factors; Antibiotic use; Pandemic; Recurrence
Core Tip	The coronavirus disease 2019 (COVID-19) pandemic was associated with an increased prevalence of Clostridium difficile infections. Previous hospitalization and antibiotic treatment are known risk factors for Clostridium difficile infection. Patients with a past history of COVID-19 infection, however, required higher doses of vancomycin and were more prone to developing recurrent disease. Rational antibiotic use should be implemented in all patients with COVID-19 infection. Diarrhea is a symptom of COVID-19 infection, which could delay the diagnosis of Clostridium difficile infection. All the patients should be tested for Clostridium difficile toxins A and B if watery diarrhea develops.
Citation	Cojocariu C, Girleanu I, Trifan A, Olteanu A, Muzica CM, Huiban L, Chiriac S, Singeap AM, Cuciureanu T, Sfarti C, Stanciu C. Did the severe acute respiratory syndrome-coronavirus 2 pandemic cause an endemic Clostridium difficile infection? World J Clin Cases 2021; 9(33): 10180-10188

Received	2021-04-28 20:21
Peer-Review Started	2021-04-28 20:24
To Make the First Decision
Return for Revision	2021-06-24 12:07
Revised	2021-07-23 10:36
Second Decision	2021-10-13 06:20
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-10-14 02:44
Articles in Press	2021-10-14 02:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-11-15 06:15

ISSN	2307-8960 (online)
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