Publication Name	World Journal of Hepatology
Manuscript ID	67782
Country	Belgium

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Step-up approach in emphysematous hepatitis: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Silke Francois, Maridi Aerts, Hendrik Reynaert, Ruth Van Lancker, Johan Van Laethem, Rastislav Kunda and Nouredin Messaoudi
Funding Agency and Grant Number
Corresponding Author	Silke Francois, MD, Attending Doctor, Doctor, Department of Gastroenterology, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, Brussels 1090, Belgium. silkefrancois@gmail.com
Key Words	Emphysematous hepatitis; Septic shock; Step-up approach; Percutaneous drainage; Laparoscopic deroofing; Case report
Core Tip	Emphysematous hepatitis (EH) is a very rare, rapidly progressive fulminant gas-forming infection of the liver parenchyma. There is a paucity of literature with regard to pathogenesis, involved organisms, imaging appearance, and management of this condition. We report the successful treatment of a patient diagnosed with EH by adopting a multimodal step-up approach including rigorous fluid resuscitation, early hemodynamic support, broad-spectrum antimicrobial therapy, and percutaneous radiologically guided drainage followed by minimal invasive surgical treatment.
Citation	Francois S, Aerts M, Reynaert H, Van Lancker R, Van Laethem J, Kunda R, Messaoudi N. Step-up approach in emphysematous hepatitis: A case report. World J Hepatol 2022; 14(2): 464-470

Received	2021-07-05 08:36
Peer-Review Started	2021-07-05 08:39
To Make the First Decision
Return for Revision	2021-08-18 02:39
Revised	2021-12-27 05:31
Second Decision	2022-01-12 03:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-01-12 21:53
Articles in Press	2022-01-12 21:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-02-10 09:53

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com