Publication Name	World Journal of Clinical Oncology
Manuscript ID	67832
Country	Greece

Category	Oncology
Manuscript Type	Review
Article Title	Hematopoietic stem cell mobilization strategies to support high-dose chemotherapy: A focus in relapsed/refractory germ-cell tumors
Manuscript Source	Invited Manuscript
All Author List	Eleni Porfyriou, Sylvia Letsa and Christos Kosmas
Funding Agency and Grant Number
Corresponding Author	Eleni Porfyriou, MD, Doctor, Department of Medical Oncology and Hematopoietic Cell Transplant Unit, “Metaxa” Cancer Hospital, 51 Botassi Street, Piraeus 18537, Greece. porfyriou7@gmail.com
Key Words	Hematopoietic stem cells; Germ-cell tumors; Hematopoietic stem cell transplantation; Granulocyte-colony-stimulating factor; Plerixafor
Core Tip	High-dose chemotherapy (HDCT) followed by autologous stem cell transplantation (ASCT) represents a curative treatment option for patients with relapsed/refractory germ-cell tumors (GCTs). Mobilization of adequate numbers of hematopoietic stem cells (HSCs) is a prerequisite for successful ASCT. As the benefit of HDCT+ASCT is largely evident with > one HDCT cycle, it is anticipated that an appreciable percentage of patients will not mobilize adequate HSCs and require salvage strategies. Herein, we review the history of HSC transplantation, with emphasis in GCTs, pathophysiological mechanisms of HSC mobilization, initial and salvage mobilization strategies, and finally discuss novel mobilizing agents and approaches to overcome failures.
Citation	Porfyriou E, Letsa S, Kosmas C. Hematopoietic stem cell mobilization strategies to support high-dose chemotherapy: A focus in relapsed/refractory germ cell tumors. World J Clin Oncol 2021; 12(9): 746-766

Received	2021-05-03 13:45
Peer-Review Started	2021-05-03 13:47
To Make the First Decision
Return for Revision	2021-06-16 04:35
Revised	2021-06-19 12:06
Second Decision	2021-07-30 03:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-07-30 08:06
Articles in Press	2021-07-30 08:06
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-08-09 21:18
Typeset the Manuscript	2021-09-16 05:17

ISSN	2218-4333 (online)
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