Publication Name	World Journal of Clinical Cases
Manuscript ID	68189
Country	China

Category	Genetics & Heredity
Manuscript Type	Case Report
Article Title	Genetic characteristics of a patient with multiple primary cancers: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Wei-Wei Ouyang, Qing-Yun Li, Wen-Gang Yang, Sheng-Fa Su, Li-Jia Wu, Ying Yang and Bing Lu
Funding Agency and Grant Number
Corresponding Author	Bing Lu, MD, Doctor, Department of Thoracic Oncology, The Affiliated Hospital of Guizhou Medical University and Cancer Hospital of Guizhou Medical University, No. 1 West Beijing Road, Yunyan District, Guiyang 550000, Guizhou Province, China. lbgymaaaa@163.com
Key Words	Multiple primary malignant neoplasms; Whole exome sequencing; Rectal carcinoma; Esophageal squamous-cell carcinoma; Gastrointestinal stromal tumour; Case report
Core Tip	We reported a case of multiple primary malignant neoplasms. In this case, next-generation whole exome sequencing confirmed that esophageal squamous-cell carcinoma and gastrointestinal stromal tumour were not genetically evolved from rectal adenocarcinoma that was removed three years ago but occurred independently. The results of next-generation whole exome sequencing of the tumour tissues confirmed the specimens’ evolution relationship.
Citation	Ouyang WW, Li QY, Yang WG, Su SF, Wu LJ, Yang Y, Lu B. Genetic characteristics of a patient with multiple primary cancers: A case report. World J Clin Cases 2021; 9(28): 8563-8570

Received	2021-05-27 09:05
Peer-Review Started	2021-05-27 09:07
To Make the First Decision
Return for Revision	2021-06-15 00:24
Revised	2021-06-28 15:46
Second Decision	2021-08-02 02:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-08-02 05:11
Articles in Press	2021-08-02 05:11
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-08-09 13:29
Typeset the Manuscript	2021-09-23 16:02

ISSN	2307-8960 (online)
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