Publication Name	World Journal of Gastroenterology
Manuscript ID	68607
Country	Italy

Category	Immunology
Manuscript Type	Basic Study
Article Title	Effects of viremia and CD4 recovery on gut “microbiome-immunity” axis in treatment-naïve HIV-1-infected patients undergoing antiretroviral therapy
Manuscript Source	Invited Manuscript
All Author List	Edda Russo, Giulia Nannini, Gaetana Sterrantino, Seble Tekle Kiros, Vincenzo Di Pilato, Marco Coppi, Simone Baldi, Elena Niccolai, Federica Ricci, Matteo Ramazzotti, Marco Pallecchi, Filippo Lagi, Gian Maria Rossolini, Alessandro Bartoloni, Gianluca Bartolucci and Amedeo Amedei
Funding Agency and Grant Number	Funding Agency Grant Number University of Florence XXXV PhD Program
Corresponding Author	Amedeo Amedei, BSc, PhD, Professor, Reader (Associate Professor), Department of Clinical and Experimental Medicine, University of Florence, Viale Pieraccini, 6, Florence 50139, Tuscany, Italy. aamedei@unifi.it
Key Words	HIV; Antiretroviral therapy; Microbiome-immunity axis; Microbiota; Cytokines; Short chain fatty acid; Inflammation; Immunological responders; Viremia
Core Tip	Even in patients receiving effective antiretroviral therapy (ART), HIV-1 infection is characterized by persistent systemic inflammation and immune activation. Changes in the gut microbiota can occur with HIV infection and treatment with ART; however, the data are still conflicting. For these reasons, we compared the fecal microbial composition and serum cytokine profile of treatment-naïve patients before starting ART and after virological suppression. Finally, we evaluated the microbiota composition, microbial metabolites, and cytokine profile of patients with CD4/CD8 ratio < 1 and CD4/CD8 > 1 (immunological responders).
Citation	Russo E, Nannini G, Sterrantino G, Kiros ST, Pilato VD, Coppi M, Baldi S, Niccolai E, Ricci F, Ramazzotti M, Pallecchi M, Lagi F, Rossolini GM, Bartoloni A, Bartolucci G, Amedei A. Effects of viremia and CD4 recovery on gut “microbiome-immunity” axis in treatment-naïve HIV-1-infected patients undergoing antiretroviral therapy. World J Gastroenterol 2022; 28(6): 635-652

Received	2021-05-28 14:31
Peer-Review Started	2021-05-28 14:35
To Make the First Decision
Return for Revision	2021-06-30 03:11
Revised	2021-07-30 10:27
Second Decision	2022-01-12 03:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-01-12 21:44
Articles in Press	2022-01-12 21:44
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-01-03 04:29
Typeset the Manuscript	2022-02-07 02:45

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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