Publication Name	World Journal of Clinical Oncology
Manuscript ID	68754
Country	Spain

Category	Oncology
Manuscript Type	Review
Article Title	Re-irradiation for high-grade gliomas: Has anything changed?
Manuscript Source	Invited Manuscript
All Author List	Sonia García-Cabezas, Eleonor Rivin del Campo, Juan Solivera-Vela and Amalia Palacios-Eito
Funding Agency and Grant Number
Corresponding Author	Amalia Palacios-Eito, MD, PhD, Associate Professor, Chief Doctor, Department of Radiation Oncology, Reina Sofia University Hospital, Avda. Menéndez Pidal, s/n, Cordoba 14004, Spain. amalia.palacios.sspa@juntadeandalucia.es
Key Words	Re-irradiation; Recurrent glioma; High-grade gliomas; Glioblastoma; Radiosurgery; Stereotactic radiotherapy
Core Tip	The optimal management after recurrence or progression of high-grade gliomas is still undefined. Improved radiation therapy techniques, new imaging methods, published experience, as well as better radiobiological knowledge of the brain tissue, have positioned re-irradiation as a valid alternative for many of these patients. Many questions remain unanswered. This review will focus on describing the most relevant studies that include reirradiation as salvage treatment, with the aim of simplifying decision-making and designing the best available therapeutic strategy.
Citation	García-Cabezas S, Rivin del Campo E, Solivera-Vela J, Palacios-Eito A. Re-irradiation for high-grade gliomas: Has anything changed? World J Clin Oncol 2021; 12(9): 767-786

Received	2021-06-02 17:41
Peer-Review Started	2021-06-02 17:44
To Make the First Decision
Return for Revision	2021-07-16 05:51
Revised	2021-07-21 08:50
Second Decision	2021-07-30 03:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-07-30 08:22
Articles in Press	2021-07-30 08:22
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-08-09 22:57
Typeset the Manuscript	2021-09-16 05:18

ISSN	2218-4333 (online)
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