Publication Name	World Journal of Clinical Cases
Manuscript ID	68824
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Is endoscopic retrograde appendicitis therapy a better modality for acute uncomplicated appendicitis? A systematic review and meta-analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Ying Wang, Chen-Yu Sun, Jie Liu, Yue Chen, Chandur Bhan, John Pocholo Whitaker Tuason, Sudha Misra, Yu-Ting Huang, Shao-Di Ma, Xing-Yu Cheng, Qin Zhou, Wen-Chao Gu, Dan-Dan Wu and Xia Chen
Funding Agency and Grant Number
Corresponding Author	Dan-Dan Wu, MSN, RN, Associate Chief Nurse, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China, NO.17 Lu Jiang Road, Hefei 230001, Anhui Province, China. 16013255@qq.com
Key Words	Endoscopic retrograde appendicitis therapy; Acute appendicitis; Meta analysis; Laparoscopic appendectomy; Randomized controlled study
Core Tip	Acute appendicitis is one of the common surgical emergencies all over the world, with a mean cost of about $9000 per procedure. It is recognized that the conventional treatment of acute appendicitis was laparoscopic appendectomy (LA), while an increasing number of surgical complications, include bleeding, adhesive intestinal obstruction, infection of the incision, and intestinal fistula, have been reported. Therefore, we conducted a meta-analysis to compare the effectiveness of endoscopic retrograde appendicitis therapy (ERAT) with standard treatment. After screening, 12 studies were included in the current systematic review and we found that, compared with LA, ERAT reduces operation time, the level of postoperative inflammation, and results in fewer complications and shorter recovery time, with preserving the appendix and its immune and biological functions.
Citation	Wang Y, Sun CY, Liu J, Chen Y, Chandur B, Tuason JPW, Misra S, Huang YT, Ma SD, Cheng XY, Zhou Q, Gu WC, Wu DD, Chen X. Is endoscopic retrograde appendicitis therapy a better modality for acute uncomplicated appendicitis? A systematic review and meta-analysis. World J Clin Cases 2021; 9(33): 10208-10221

Received	2021-06-05 08:29
Peer-Review Started	2021-06-05 08:33
To Make the First Decision
Return for Revision	2021-06-29 12:56
Revised	2021-08-01 13:11
Second Decision	2021-10-11 08:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-10-14 02:40
Articles in Press	2021-10-14 02:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-11-15 02:02

ISSN	2307-8960 (online)
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