Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	70355
Country	Portugal

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Neutrophile-to-lymphocyte, lymphocyte-to-monocyte, and platelet-to-lymphocyte ratios as prognostic and response biomarkers for resectable locally advanced gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Tiago Cruz Tomás, Inês Eiriz, Marina Vitorino, Rodrigo Vicente, João Gramaça, Alicia Guadalupe Oliveira, Paulo Luz, Mafalda Baleiras, Ana Sofia Spencer, Luísa Leal Costa, Patrícia Liu, Joana Mendonça, Magno Dinis, Teresa Padrão, Marisol Correia, Gonçalo Atalaia, Michelle Silva and Teresa Fiúza
Funding Agency and Grant Number
Corresponding Author	Tiago Cruz Tomás, MD, Doctor, Department of Medical Oncology, Hospital Professor Doutor Fernando Fonseca EPE, IC 19, Amadora 2720-276, Portugal. tiago.tomas@campus.ul.pt
Key Words	Gastric cancer; Perioperative fluorouracil plus leucovorin, oxaliplatin, and docetaxel; Neutrophil-to-lymphocyte; Lymphocyte-to-monocyte; Platelet-to-lymphocyte; Tumor regression grade
Core Tip	Fluorouracil plus leucovorin, oxaliplatin, and docetaxel (FLOT) perioperative regimen has become the standard of care for resectable locally advanced gastric cancer, but there is a need for prognostic and predictive biomarkers. Neutrophil-to-lymphocyte (NLR), lymphocyte-to-monocyte (LMR), and platelet-to-lymphocyte (PLR) ratios are useful in solid tumors. We performed exploratory analyses regarding pathological response prediction and survival outcomes. NLR is weakly correlated with overall survival, high LMR patients have higher risk of T stage regression, high PLR patients have higher odds of progressing under FLOT and higher risk of mortality, and patients without T stage or pathological regression have higher risk of dying.
Citation	Tomás TC, Eiriz I, Vitorino M, Vicente R, Gramaça J, Oliveira AG, Luz P, Baleiras M, Spencer AS, Costa LL, Liu P, Mendonça J, Dinis M, Padrão T, Correia M, Atalaia G, Silva M, Fiúza T. Neutrophile-to-lymphocyte, lymphocyte-to-monocyte, and platelet-to-lymphocyte ratios as prognostic and response biomarkers for resectable locally advanced gastric cancer. World J Gastrointest Oncol 2022; 14(7): 1307-1323

Received	2021-08-02 21:55
Peer-Review Started	2021-08-02 21:58
To Make the First Decision
Return for Revision	2021-09-05 07:43
Revised	2021-09-19 20:40
Second Decision	2022-06-21 03:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-06-26 23:41
Articles in Press	2022-06-26 23:41
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-06-14 20:06
Typeset the Manuscript	2022-07-02 07:37

ISSN	1948-5204 (online)
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